Structural Determinants of the Supramolecular Organization of G Protein-Coupled Receptors in Bilayers

The G protein-coupled receptor (GPCR) rhodopsin self-assembles into supramolecular structures in native bilayers, but the structural determinants of receptor oligomerization are not known. We carried out multiple self-assembly coarse-grained molecular dynamics (CGMD) simulations of model membranes c...

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Veröffentlicht in:	Journal of the American Chemical Society 2012-07, Vol.134 (26), p.10959-10965
Hauptverfasser:	Periole, Xavier, Knepp, Adam M., Sakmar, Thomas P., Marrink, Siewert J., Huber, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	crosslinking dimerization electron microscopy energy G-protein coupled receptors Gibbs free energy Membrane Proteins - chemistry molecular dynamics Molecular Dynamics Simulation oligomerization Protein Multimerization Protein Structure, Quaternary Receptors, G-Protein-Coupled - chemistry rhodopsin Rhodopsin - chemistry transmembrane proteins X-radiation
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