A neurotrophic hypothesis of depression: role of synaptogenesis in the actions of NMDA receptor antagonists

Molecular and cellular studies have demonstrated opposing actions of stress and antidepressant treatment on the expression of neurotrophic factors, particularly brain-derived neurotrophic factor, in limbic structures of the brain. These changes in neurotrophic factor expression and function result i...

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Veröffentlicht in:	Philosophical transactions of the Royal Society of London. Series B. Biological sciences 2012-09, Vol.367 (1601), p.2475-2484
Hauptverfasser:	Duman, Ronald S., Li, Nanxin
Format:	Artikel
Sprache:	eng
Schlagworte:	AMPA receptors Animals Antidepressants Antidepressive Agents - pharmacology Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - metabolism Dendrites Dendrites - genetics Dendrites - metabolism Dendrites - pathology Depression - physiopathology Depressive disorders Gene-Environment Interaction Genetic variation Glutamate Hippocampus Humans Ketamine Ketamine - pharmacology Mammalian Target Of Rapamycin N methyl D aspartate receptors Neurogenesis Neurons Rapamycin Receptors Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Review Signal Transduction Sirolimus - pharmacology Spine Stress Stress, Psychological - physiopathology Synapses - drug effects Synapses - metabolism TOR Serine-Threonine Kinases - genetics TOR Serine-Threonine Kinases - metabolism
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