Early Detection of Human Immunodeficiency Virus Infection among Kenyan Infants Using a Reverse Transcriptase Activity Assay

Early Detection of Human Immunodeficiency Virus Infection among Kenyan Infants Using a Reverse Transcriptase Activity Assay

Two hundred HIV-exposed Kenyan infants were tested for HIV infection at birth and at age 6,12, 24 and 48 weeks, by DNA PCR and Cavidi reverse transcriptase (RT) assays and after age 18 months by HIV antibody test. Eleven (5.5%) infants became HIV infected. In six, positive RT preceded positive DNA P...

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Veröffentlicht in:The Pediatric infectious disease journal 2012-07, Vol.31 (7), p.732-735
Hauptverfasser: Sivapalasingam, Sumathi, Ahmed, Aabid, Mendillo, Megan, Holzman, Robert, Marshed, Fatuma, Mwamzuka, Musa, Khamadi, Samuel, Mwau, Matilu, Laverty, Maura, Valentine, Fred
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container_issue 7
container_start_page 732
container_title The Pediatric infectious disease journal
container_volume 31
creator Sivapalasingam, Sumathi
Ahmed, Aabid
Mendillo, Megan
Holzman, Robert
Marshed, Fatuma
Mwamzuka, Musa
Khamadi, Samuel
Mwau, Matilu
Laverty, Maura
Valentine, Fred
description Two hundred HIV-exposed Kenyan infants were tested for HIV infection at birth and at age 6,12, 24 and 48 weeks, by DNA PCR and Cavidi reverse transcriptase (RT) assays and after age 18 months by HIV antibody test. Eleven (5.5%) infants became HIV infected. In six, positive RT preceded positive DNA PCR. Use of RT assay may facilitate earlier HIV diagnosis in infants.
doi_str_mv 10.1097/INF.0b013e318259bc1e
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title Early Detection of Human Immunodeficiency Virus Infection among Kenyan Infants Using a Reverse Transcriptase Activity Assay
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