Diosgenin is an exogenous activator of 1,25D3-MARRS/Pdia3/ERp57 and improves Alzheimer's disease pathologies in 5XFAD mice

The aim of this study was to investigate the effects and the mechanism of diosgenin, a famous plant-derived steroidal sapogenin, on memory deficits in Alzheimer's disease (AD) model mice. Diosgenin-treated 5XFAD mice exhibited significantly improved performance of object recognition memory. Dio...

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Veröffentlicht in:	Scientific reports 2012-07, Vol.2 (1), p.535-535, Article 535
Hauptverfasser:	Tohda, Chihiro, Urano, Takuya, Umezaki, Masahito, Nemere, Ilka, Kuboyama, Tomoharu
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154/309/555 631/378/1689/364 631/378/87 Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Amyloid Animals Antibodies, Monoclonal - immunology Antibodies, Monoclonal - pharmacology Antibodies, Neutralizing - immunology Antibodies, Neutralizing - pharmacology Atrophy Axon guidance Axons - drug effects Cerebellar Cortex - drug effects Cerebellar Cortex - metabolism Cerebral cortex Diosgenin - administration & dosage Diosgenin - chemistry Diosgenin - pharmacology Disease Models, Animal Female Gene Knockdown Techniques Humanities and Social Sciences Male Memory Disorders - drug therapy Memory Disorders - metabolism Mice Molecular Docking Simulation multidisciplinary Neurodegenerative diseases Neurofibrillary tangles Neurons - drug effects Neurons - metabolism Pattern recognition Plants Plaque, Amyloid Presynaptic Terminals - drug effects Protein Conformation Protein Disulfide-Isomerases - chemistry Protein Disulfide-Isomerases - genetics Protein Disulfide-Isomerases - immunology Protein Disulfide-Isomerases - metabolism Protein Kinase Inhibitors - pharmacology Regeneration Science Senile plaques
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