Discovery of novel sulfonated small molecules that inhibit vascular tube formation

Tumor-associated angiogenesis is a complex process that involves the interplay among several molecular players such as cell-surface heparan sulfate proteoglycans, vascular endothelial growth factors and their cognate receptors. PI-88, a highly sulfonated oligosaccharide, has been shown to have poten...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2012-07, Vol.22 (13), p.4467-4470
Hauptverfasser:	Raman, Karthik, Karuturi, Rajesh, Swarup, Vimal P., Desai, Umesh R., Kuberan, Balagurunathan
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis angiogenesis inhibitors Angiogenesis Inhibitors - chemical synthesis Angiogenesis Inhibitors - chemistry Angiogenesis Inhibitors - pharmacology Animals Biological and medical sciences Biomimetic Materials - chemical synthesis Biomimetic Materials - chemistry Biomimetic Materials - pharmacology Carbohydrates Cattle chemistry Clinical trials Drug Evaluation, Preclinical Endothelial Cells - cytology Endothelial Cells - drug effects heparan sulfate Heparan sulfate proteoglycans Inhibitors Matrigel Medical sciences Microtubules - drug effects Microtubules - metabolism oligosaccharides Oligosaccharides - pharmacology Pharmacology. Drug treatments Polysulfonated molecules proteoglycans receptors Small Molecule Libraries - chemical synthesis Small Molecule Libraries - chemistry Small Molecule Libraries - pharmacology Small molecules Sulfur - chemistry Vascular endothelial growth factor vascular endothelial growth factors
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