Resveratrol suppresses growth of cancer stem-like cells by inhibiting fatty acid synthase

Resveratrol is a natural polyphenolic compound and has been shown to exhibit cardio-protective as well as anti-neoplastic effects on various types of cancers. However, the exact mechanism of its anti-tumor effect is not clearly defined. Resveratrol has been shown to have strong hypolipidemic effect...

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Veröffentlicht in:	Breast cancer research and treatment 2011-11, Vol.130 (2), p.387-398
Hauptverfasser:	Pandey, Puspa R., Okuda, Hiroshi, Watabe, Misako, Pai, Sudha K., Liu, Wen, Kobayashi, Aya, Xing, Fei, Fukuda, Koji, Hirota, Shigeru, Sugai, Tamotsu, Wakabayashi, Go, Koeda, Keisuke, Kashiwaba, Masahiro, Suzuki, Kazuyuki, Chiba, Toshimi, Endo, Masaki, Fujioka, Tomoaki, Tanji, Susumu, Mo, Yin-Yuan, Cao, Deliang, Wilber, Andrew C., Watabe, Kounosuke
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents, Phytogenic - pharmacology Apoptosis Apoptosis - drug effects Apoptosis - genetics Apoptosis Regulatory Proteins - genetics Apoptosis Regulatory Proteins - metabolism Biological and medical sciences Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - pathology Calcium-Calmodulin-Dependent Protein Kinases - genetics Calcium-Calmodulin-Dependent Protein Kinases - metabolism Cancer Cancer research Cancer therapies Cell Proliferation - drug effects Cell Survival - drug effects Cellular biology Death-Associated Protein Kinases Fatty Acid Synthases - antagonists & inhibitors Fatty Acid Synthases - genetics Fatty Acid Synthases - metabolism Fatty acids Female Gene Expression Gene Knockdown Techniques Growth Gynecology. Andrology. Obstetrics Humans Lipogenesis - drug effects Mammary gland diseases Medical sciences Medicine Medicine & Public Health Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Nude Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism Oncology Phytochemicals Preclinical Study Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Resveratrol RNA Interference Stilbenes - pharmacology Synthesis Tumors Xenograft Model Antitumor Assays
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