Multiple ligand-specific conformations of the β2-adrenergic receptor

A quantitative covalent labeling strategy reveals that multiple ligand-specific conformational states are present in the G protein–coupled β 2 -adrenergic receptor. Their existence may underlie 'biased agonism', which describes the differential abilities of agonists to activate distinct si...

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Veröffentlicht in:	Nature chemical biology 2011-08, Vol.7 (10), p.692-700
Hauptverfasser:	Kahsai, Alem W, Xiao, Kunhong, Rajagopal, Sudarshan, Ahn, Seungkirl, Shukla, Arun K, Sun, Jinpeng, Oas, Terrence G, Lefkowitz, Robert J
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45/535 631/57/2272/2273 Adaptor proteins Adrenergic receptors Biochemical Engineering Biochemistry Bioorganic Chemistry Cell Biology Chemical compounds Chemistry Chemistry and Materials Science Chemistry/Food Science Drug development Humans Ligands Mass Spectrometry Mass spectroscopy Molecular Conformation Pharmacology Proteins Reactivity Receptors Receptors (physiology) Receptors, Adrenergic, beta-2 - chemistry Receptors, Adrenergic, beta-2 - metabolism Signaling Therapeutic targets
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