Proinflammatory Actions of Glucocorticoids: Glucocorticoids and TNFα Coregulate Gene Expression In Vitro and In Vivo

Synthetic glucocorticoids are widely used for treatment of many inflammatory diseases. However, long-term glucocorticoid treatment can cause a variety of negative side effects. A genome-wide microarray analysis was performed in human lung A549 cells to identify genes regulated by both the antiinflam...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2012-08, Vol.153 (8), p.3701-3712
Hauptverfasser:	Lannan, Erica A, Galliher-Beckley, Amy J, Scoltock, Alyson B, Cidlowski, John A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute phase proteins Animals Biological and medical sciences Blotting, Western Cell Line Chromatin Chromatin Immunoprecipitation Dexamethasone Dexamethasone - metabolism Dexamethasone - pharmacology DNA microarrays Fundamental and applied biological sciences. Psychology Gene expression Gene Expression - drug effects Genes Genomic analysis Glucocorticoid receptors Glucocorticoids Glucocorticoids - metabolism Glucocorticoids - pharmacology Glucocorticoids-CRH-ACTH-Adrenal Health services Human performance Humans Immunoprecipitation In vivo methods and tests Inflammatory diseases Lungs Male Mice Protein Binding Protein folding Real-Time Polymerase Chain Reaction Receptors Receptors, Glucocorticoid - genetics Receptors, Glucocorticoid - metabolism Receptors, Tumor Necrosis Factor - genetics Receptors, Tumor Necrosis Factor - metabolism Serpins - genetics Serpins - metabolism Side effects Tumor Necrosis Factor-alpha - metabolism Tumor Necrosis Factor-alpha - pharmacology Tumor necrosis factor-α Vertebrates: endocrinology
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