Estrogen receptor-β protects against colitis-associated neoplasia in mice

Estrogen receptor‐beta (ERβ) has been suggested to exert anti‐inflammatory and anti‐tumorigenic effects in the colon, providing a translational potential to prevent and/or treat inflammatory bowel disease (IBD) and its progression to colitis‐associated colorectal cancer (CAC). However, the specific...

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Veröffentlicht in:	International journal of cancer 2012-12, Vol.131 (11), p.2553-2561
Hauptverfasser:	Saleiro, Diana, Murillo, Genoveva, Benya, Richard V., Bissonnette, Marc, Hart, John, Mehta, Rajendra G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals azoxymethane beta Catenin - genetics beta Catenin - metabolism Biological and medical sciences Caveolin 1 - genetics Caveolin 1 - metabolism Cell Differentiation - genetics Colitis - genetics Colitis - metabolism Colitis - pathology Colon - metabolism Colon - pathology colon cancer Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology dextran sodium sulfate Estradiol - blood Estrogen Receptor beta - genetics Estrogen Receptor beta - metabolism estrogen receptor-beta Female Gastroenterology. Liver. Pancreas. Abdomen Inflammation - genetics Inflammation - metabolism Inflammation - pathology inflammatory bowel disease Inflammatory Bowel Diseases - genetics Inflammatory Bowel Diseases - metabolism Inflammatory Bowel Diseases - pathology Interferon-gamma - genetics Interferon-gamma - metabolism Interleukin-17 - genetics Interleukin-17 - metabolism Interleukin-6 - genetics Interleukin-6 - metabolism Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Mucin-1 - genetics Mucin-1 - metabolism Mucin-2 - genetics Mucin-2 - metabolism Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology NF-kappa B - genetics NF-kappa B - metabolism Nitric Oxide Synthase Type II - genetics Nitric Oxide Synthase Type II - metabolism Other diseases. Semiology Proliferating Cell Nuclear Antigen - genetics Proliferating Cell Nuclear Antigen - metabolism Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism Tumors
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