Interaction Between Serotonin Transporter Polymorphism (5-HTTLPR) and Stressful Life Events in Adolescents' Trajectories of Anxious/Depressed Symptoms
Caspi et al. (2003) found an interaction between the serotonin transporter polymorphism gene (5-HTTLPR) and stressful life events on depression. Subsequent attempts to replicate have been inconsistent. The present research included long allele variants modified by SNP rs25531 and tested the interact...
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| Veröffentlicht in: | Developmental psychology 2012-09, Vol.48 (5), p.1463-1475 |
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| creator | PETERSEN, Isaac T BATES, John E GOODNIGHT, Jackson A DODGE, Kenneth A LANSFORD, Jennifer E PETTIT, Gregory S LATENDRESSE, Shawn J DICK, Danielle M |
| description | Caspi et al. (2003) found an interaction between the serotonin transporter polymorphism gene (5-HTTLPR) and stressful life events on depression. Subsequent attempts to replicate have been inconsistent. The present research included long allele variants modified by SNP rs25531 and tested the interaction on adolescents' trajectories of anxious/depressed symptoms, with consideration of possible age effects. Adolescents (N = 574), of whom 436 were genotyped, were followed from ages 12 to 17. Analyses demonstrated a G × E interaction in predicting the development of anxious/depressed symptoms. Specifically, adolescents with lower serotonin transcriptional efficiency (TE) genotypes whose mothers reported more stressful events were reported to show more anxious/depressed symptoms and greater increases in the development of symptoms of anxiety and depression than were higher TE adolescents, particularly at ages 16 and 17. Interactions did not differ by gender. Findings demonstrate that stress may affect adolescents' likelihood of experiencing anxious/depressed symptoms when they have a low serotonin TE (A/G-modified 5-HTTLPR) genotype and suggest that the vulnerability may be stronger in late than early adolescence. |
| doi_str_mv | 10.1037/a0027471 |
| format | Article |
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(2003) found an interaction between the serotonin transporter polymorphism gene (5-HTTLPR) and stressful life events on depression. Subsequent attempts to replicate have been inconsistent. The present research included long allele variants modified by SNP rs25531 and tested the interaction on adolescents' trajectories of anxious/depressed symptoms, with consideration of possible age effects. Adolescents (N = 574), of whom 436 were genotyped, were followed from ages 12 to 17. Analyses demonstrated a G × E interaction in predicting the development of anxious/depressed symptoms. Specifically, adolescents with lower serotonin transcriptional efficiency (TE) genotypes whose mothers reported more stressful events were reported to show more anxious/depressed symptoms and greater increases in the development of symptoms of anxiety and depression than were higher TE adolescents, particularly at ages 16 and 17. Interactions did not differ by gender. Findings demonstrate that stress may affect adolescents' likelihood of experiencing anxious/depressed symptoms when they have a low serotonin TE (A/G-modified 5-HTTLPR) genotype and suggest that the vulnerability may be stronger in late than early adolescence.</description><identifier>ISSN: 0012-1649</identifier><identifier>EISSN: 1939-0599</identifier><identifier>DOI: 10.1037/a0027471</identifier><identifier>PMID: 22390669</identifier><identifier>CODEN: DEVPA9</identifier><language>eng</language><publisher>Washington, DC: American Psychological Association</publisher><subject>Adolescence ; Adolescent ; Adolescent Psychopathology ; Adolescents ; Adult and adolescent clinical studies ; Anxiety ; Anxiety - genetics ; Anxiety disorders ; Anxiety-Depression ; Biological and medical sciences ; Child ; Depression ; Depression (Psychology) ; Depression - genetics ; Developmental psychology ; DNA Mutational Analysis ; Early Adolescents ; Family Relations ; Female ; Forecasts ; Fundamental and applied biological sciences. Psychology ; Gender ; Gene-Environment Interaction ; Genes ; Genotype ; Genotype & phenotype ; Human ; Humans ; Indiana ; Life Change Events ; Major Depression ; Male ; Medical sciences ; Mental depression ; Mental stress ; Mood disorders ; Mothers - psychology ; Neurotransmitter Transporters ; Polymorphism ; Polymorphism, Single Nucleotide ; Predictive Value of Tests ; Psychiatric Status Rating Scales ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Psychopathology. 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(2003) found an interaction between the serotonin transporter polymorphism gene (5-HTTLPR) and stressful life events on depression. Subsequent attempts to replicate have been inconsistent. The present research included long allele variants modified by SNP rs25531 and tested the interaction on adolescents' trajectories of anxious/depressed symptoms, with consideration of possible age effects. Adolescents (N = 574), of whom 436 were genotyped, were followed from ages 12 to 17. Analyses demonstrated a G × E interaction in predicting the development of anxious/depressed symptoms. Specifically, adolescents with lower serotonin transcriptional efficiency (TE) genotypes whose mothers reported more stressful events were reported to show more anxious/depressed symptoms and greater increases in the development of symptoms of anxiety and depression than were higher TE adolescents, particularly at ages 16 and 17. Interactions did not differ by gender. Findings demonstrate that stress may affect adolescents' likelihood of experiencing anxious/depressed symptoms when they have a low serotonin TE (A/G-modified 5-HTTLPR) genotype and suggest that the vulnerability may be stronger in late than early adolescence.</description><subject>Adolescence</subject><subject>Adolescent</subject><subject>Adolescent Psychopathology</subject><subject>Adolescents</subject><subject>Adult and adolescent clinical studies</subject><subject>Anxiety</subject><subject>Anxiety - genetics</subject><subject>Anxiety disorders</subject><subject>Anxiety-Depression</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Depression</subject><subject>Depression (Psychology)</subject><subject>Depression - genetics</subject><subject>Developmental psychology</subject><subject>DNA Mutational Analysis</subject><subject>Early Adolescents</subject><subject>Family Relations</subject><subject>Female</subject><subject>Forecasts</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gender</subject><subject>Gene-Environment Interaction</subject><subject>Genes</subject><subject>Genotype</subject><subject>Genotype & phenotype</subject><subject>Human</subject><subject>Humans</subject><subject>Indiana</subject><subject>Life Change Events</subject><subject>Major Depression</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mental depression</subject><subject>Mental stress</subject><subject>Mood disorders</subject><subject>Mothers - psychology</subject><subject>Neurotransmitter Transporters</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Predictive Value of Tests</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Psychopathology. Psychiatry</subject><subject>Serotonin</subject><subject>Serotonin Plasma Membrane Transport Proteins - genetics</subject><subject>Statistics as Topic</subject><subject>Stress</subject><subject>Stressful events</subject><subject>Symptoms</subject><subject>Teenagers</subject><subject>Tennessee</subject><issn>0012-1649</issn><issn>1939-0599</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqFkt9qFDEUhwdR7FoFn0CCItaLsfk3meRG2NZqCwsWu14PafbEZplJpslM676Iz2tGt60K0qtwyJcv5xx-RfGc4HcEs3pfY0xrXpMHxYwopkpcKfWwmGFMaEkEVzvFk5TWueRMVY-LHUqZwkKoWfHjxA8QtRlc8OgAhmsAj84ghiF459Eyap_6EDODTkO76ULsL1zq0F5VHi-Xi9Mvb5H2K3Q2REjJji1aOAvo6Ar8kFAWzFehhWSm8s1kW4MZQnSQULBo7r-7MKb9D9BPzyF7Nl0_hC49LR5Z3SZ4tj13i68fj5aHx-Xi86eTw_miNJVUQwmacllLkNZobbQSFa_rClOiraqoNgRbSy3njOJMGg20FkoqTYCd49pwtlu8_-3tx_MOVlOfUbdNH12n46YJ2jV_33h30XwLVw3jmBOBs2BvK4jhcoQ0NJ3L47at9pBHawgnkhAmpLwfZYLXQnAm7kfxZMRS0Yy-_AddhzH6vLRG0WwjVVVn6NX_oCk_jAtesbtfTQwpRbC3eyD4F9fc5CyjL_7c2y14E6wMvN4COhnd2pwj49IdJ6gkNHf2EwAF2nA</recordid><startdate>20120901</startdate><enddate>20120901</enddate><creator>PETERSEN, Isaac T</creator><creator>BATES, John E</creator><creator>GOODNIGHT, Jackson A</creator><creator>DODGE, Kenneth A</creator><creator>LANSFORD, Jennifer E</creator><creator>PETTIT, Gregory S</creator><creator>LATENDRESSE, Shawn J</creator><creator>DICK, Danielle M</creator><general>American Psychological Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope><scope>8BJ</scope><scope>FQK</scope><scope>JBE</scope><scope>K7.</scope><scope>7RZ</scope><scope>PSYQQ</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3072-6673</orcidid></search><sort><creationdate>20120901</creationdate><title>Interaction Between Serotonin Transporter Polymorphism (5-HTTLPR) and Stressful Life Events in Adolescents' Trajectories of Anxious/Depressed Symptoms</title><author>PETERSEN, Isaac T ; BATES, John E ; GOODNIGHT, Jackson A ; DODGE, Kenneth A ; LANSFORD, Jennifer E ; PETTIT, Gregory S ; LATENDRESSE, Shawn J ; DICK, Danielle M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c589t-ea24878e8fcaaca9654775021af952ac10ff2f44320a24cae276989a1e3b07c43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescence</topic><topic>Adolescent</topic><topic>Adolescent Psychopathology</topic><topic>Adolescents</topic><topic>Adult and adolescent clinical studies</topic><topic>Anxiety</topic><topic>Anxiety - genetics</topic><topic>Anxiety disorders</topic><topic>Anxiety-Depression</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Depression</topic><topic>Depression (Psychology)</topic><topic>Depression - genetics</topic><topic>Developmental psychology</topic><topic>DNA Mutational Analysis</topic><topic>Early Adolescents</topic><topic>Family Relations</topic><topic>Female</topic><topic>Forecasts</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gender</topic><topic>Gene-Environment Interaction</topic><topic>Genes</topic><topic>Genotype</topic><topic>Genotype & phenotype</topic><topic>Human</topic><topic>Humans</topic><topic>Indiana</topic><topic>Life Change Events</topic><topic>Major Depression</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mental depression</topic><topic>Mental stress</topic><topic>Mood disorders</topic><topic>Mothers - psychology</topic><topic>Neurotransmitter Transporters</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Predictive Value of Tests</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Psychopathology. Psychiatry</topic><topic>Serotonin</topic><topic>Serotonin Plasma Membrane Transport Proteins - genetics</topic><topic>Statistics as Topic</topic><topic>Stress</topic><topic>Stressful events</topic><topic>Symptoms</topic><topic>Teenagers</topic><topic>Tennessee</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PETERSEN, Isaac T</creatorcontrib><creatorcontrib>BATES, John E</creatorcontrib><creatorcontrib>GOODNIGHT, Jackson A</creatorcontrib><creatorcontrib>DODGE, Kenneth A</creatorcontrib><creatorcontrib>LANSFORD, Jennifer E</creatorcontrib><creatorcontrib>PETTIT, Gregory S</creatorcontrib><creatorcontrib>LATENDRESSE, Shawn J</creatorcontrib><creatorcontrib>DICK, Danielle M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>International Bibliography of the Social Sciences (IBSS)</collection><collection>International Bibliography of the Social Sciences</collection><collection>International Bibliography of the Social Sciences</collection><collection>ProQuest Criminal Justice (Alumni)</collection><collection>APA PsycArticles®</collection><collection>ProQuest One Psychology</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Developmental psychology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PETERSEN, Isaac T</au><au>BATES, John E</au><au>GOODNIGHT, Jackson A</au><au>DODGE, Kenneth A</au><au>LANSFORD, Jennifer E</au><au>PETTIT, Gregory S</au><au>LATENDRESSE, Shawn J</au><au>DICK, Danielle M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interaction Between Serotonin Transporter Polymorphism (5-HTTLPR) and Stressful Life Events in Adolescents' Trajectories of Anxious/Depressed Symptoms</atitle><jtitle>Developmental psychology</jtitle><addtitle>Dev Psychol</addtitle><date>2012-09-01</date><risdate>2012</risdate><volume>48</volume><issue>5</issue><spage>1463</spage><epage>1475</epage><pages>1463-1475</pages><issn>0012-1649</issn><eissn>1939-0599</eissn><coden>DEVPA9</coden><abstract>Caspi et al. (2003) found an interaction between the serotonin transporter polymorphism gene (5-HTTLPR) and stressful life events on depression. Subsequent attempts to replicate have been inconsistent. The present research included long allele variants modified by SNP rs25531 and tested the interaction on adolescents' trajectories of anxious/depressed symptoms, with consideration of possible age effects. Adolescents (N = 574), of whom 436 were genotyped, were followed from ages 12 to 17. Analyses demonstrated a G × E interaction in predicting the development of anxious/depressed symptoms. Specifically, adolescents with lower serotonin transcriptional efficiency (TE) genotypes whose mothers reported more stressful events were reported to show more anxious/depressed symptoms and greater increases in the development of symptoms of anxiety and depression than were higher TE adolescents, particularly at ages 16 and 17. Interactions did not differ by gender. Findings demonstrate that stress may affect adolescents' likelihood of experiencing anxious/depressed symptoms when they have a low serotonin TE (A/G-modified 5-HTTLPR) genotype and suggest that the vulnerability may be stronger in late than early adolescence.</abstract><cop>Washington, DC</cop><pub>American Psychological Association</pub><pmid>22390669</pmid><doi>10.1037/a0027471</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0003-3072-6673</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescence Adolescent Adolescent Psychopathology Adolescents Adult and adolescent clinical studies Anxiety Anxiety - genetics Anxiety disorders Anxiety-Depression Biological and medical sciences Child Depression Depression (Psychology) Depression - genetics Developmental psychology DNA Mutational Analysis Early Adolescents Family Relations Female Forecasts Fundamental and applied biological sciences. Psychology Gender Gene-Environment Interaction Genes Genotype Genotype & phenotype Human Humans Indiana Life Change Events Major Depression Male Medical sciences Mental depression Mental stress Mood disorders Mothers - psychology Neurotransmitter Transporters Polymorphism Polymorphism, Single Nucleotide Predictive Value of Tests Psychiatric Status Rating Scales Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychopathology. Psychiatry Serotonin Serotonin Plasma Membrane Transport Proteins - genetics Statistics as Topic Stress Stressful events Symptoms Teenagers Tennessee |
| title | Interaction Between Serotonin Transporter Polymorphism (5-HTTLPR) and Stressful Life Events in Adolescents' Trajectories of Anxious/Depressed Symptoms |
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