Can a Gleason 6 or Less Microfocus of Prostate Cancer in One Biopsy and Prostate-Specific Antigen Level ＜10 ng/mL Be Defined as the Archetype of Low-Risk Prostate Disease?
Prostate cancer (PC) remains a cause of death worldwide. Here we investigate whether a single microfocus of PC at the biopsy (graded as Gleason 6 or less, ≤5% occupancy) and the PSA
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| Veröffentlicht in: | Journal of Oncology 2012-01, Vol.2012 (2012), p.486-491-051 |
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| container_end_page | 491-051 |
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| container_issue | 2012 |
| container_start_page | 486 |
| container_title | Journal of Oncology |
| container_volume | 2012 |
| creator | Taverna, Gianluigi Benecchi, Luigi Grizzi, Fabio Seveso, Mauro Giusti, Guido Piccinelli, Alessandro Benetti, Alessio Colombo, Piergiuseppe Minuti, Francesco Graziotti, Pierpaolo |
| description | Prostate cancer (PC) remains a cause of death worldwide. Here we investigate whether a single microfocus of PC at the biopsy (graded as Gleason 6 or less, ≤5% occupancy) and the PSA |
| doi_str_mv | 10.1155/2012/645146 |
| format | Article |
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Here we investigate whether a single microfocus of PC at the biopsy (graded as Gleason 6 or less, ≤5% occupancy) and the PSA <10 ng/mL can define the archetype of low-risk prostate disease. 4500 consecutive patients were enrolled. Among them, 134 patients with a single micro-focus of PC were followed up, and the parameters influencing the biochemical relapse (BR) were analysed. Out of 134 patients, 94 had clinically significant disease, specifically in 74.26% of the patients with PSA <10 ng/mL. Positive surgical margins and the extracapsular invasion were found in 29.1% and 51.4% patients, respectively. BR was observed in 29.6% of the patients. Cox regression evidenced a correlation between the BR and Gleason grade at the retropubic radical prostatectomy (RRP), capsular invasion, and the presence of positive surgical margins. Multivariate regression analysis showed a statistically significant correlation between the presence of surgical margins at the RRP and BR. Considering a single micro-focus of PC at the biopsy and PSA serum level <10 ng/mL, clinically significant disease was found in 74.26% patients and only positive surgical margins are useful for predicting the BR.</description><identifier>ISSN: 1687-8450</identifier><identifier>EISSN: 1687-8450</identifier><identifier>DOI: 10.1155/2012/645146</identifier><identifier>PMID: 22848218</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Limiteds</publisher><ispartof>Journal of Oncology, 2012-01, Vol.2012 (2012), p.486-491-051</ispartof><rights>Copyright © 2012 Gianluigi Taverna et al.</rights><rights>Copyright © 2012 Gianluigi Taverna et al. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a441t-6cda11f1a7303aff841819b86e49478b215bc6e9ef7358221a012501d201bc8f3</citedby><cites>FETCH-LOGICAL-a441t-6cda11f1a7303aff841819b86e49478b215bc6e9ef7358221a012501d201bc8f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3403479/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3403479/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22848218$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Roach, M.</contributor><creatorcontrib>Taverna, Gianluigi</creatorcontrib><creatorcontrib>Benecchi, Luigi</creatorcontrib><creatorcontrib>Grizzi, Fabio</creatorcontrib><creatorcontrib>Seveso, Mauro</creatorcontrib><creatorcontrib>Giusti, Guido</creatorcontrib><creatorcontrib>Piccinelli, Alessandro</creatorcontrib><creatorcontrib>Benetti, Alessio</creatorcontrib><creatorcontrib>Colombo, Piergiuseppe</creatorcontrib><creatorcontrib>Minuti, Francesco</creatorcontrib><creatorcontrib>Graziotti, Pierpaolo</creatorcontrib><title>Can a Gleason 6 or Less Microfocus of Prostate Cancer in One Biopsy and Prostate-Specific Antigen Level ＜10 ng/mL Be Defined as the Archetype of Low-Risk Prostate Disease?</title><title>Journal of Oncology</title><addtitle>J Oncol</addtitle><description>Prostate cancer (PC) remains a cause of death worldwide. Here we investigate whether a single microfocus of PC at the biopsy (graded as Gleason 6 or less, ≤5% occupancy) and the PSA <10 ng/mL can define the archetype of low-risk prostate disease. 4500 consecutive patients were enrolled. Among them, 134 patients with a single micro-focus of PC were followed up, and the parameters influencing the biochemical relapse (BR) were analysed. Out of 134 patients, 94 had clinically significant disease, specifically in 74.26% of the patients with PSA <10 ng/mL. Positive surgical margins and the extracapsular invasion were found in 29.1% and 51.4% patients, respectively. BR was observed in 29.6% of the patients. Cox regression evidenced a correlation between the BR and Gleason grade at the retropubic radical prostatectomy (RRP), capsular invasion, and the presence of positive surgical margins. Multivariate regression analysis showed a statistically significant correlation between the presence of surgical margins at the RRP and BR. Considering a single micro-focus of PC at the biopsy and PSA serum level <10 ng/mL, clinically significant disease was found in 74.26% patients and only positive surgical margins are useful for predicting the BR.</description><issn>1687-8450</issn><issn>1687-8450</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><recordid>eNqFks1u1DAUhSMEoqWwYg3yEoHC-CZO4myKplMoSIM64mdtOc71jEvGHuyk1bwLr8Ab8E68Ap6mDO2KhWVb99O51-c4SZ4CfQ1QFJOMQjYpWQGsvJccQsmrlLOC3r91PkgehXBBacloXT5MDrKMM54BP0x-zqQlkpx1KIOzpCTOkzmGQD4a5Z12agjEabLwLvSyRxJxhZ4YS84tkhPjNmFLpG33RPp5g8poo8jU9maJNspdYkd-__oBlNjlZD0nJ0hOURuLLZGB9CskU69W2G83uGs2d1fpJxO-_et6akKcD988Th5o2QV8crMfJV_fvf0ye5_Oz88-zKbzVDIGfVqqVgJokFVOc6k1Z8ChbniJrGYVbzIoGlVijbrKC55lIKOFBYU2WtkorvOj5HjU3QzNGluFtveyExtv1tJvhZNG3K1YsxJLdylyRnNW1VHgxY2Ad98HDL1Ym6Cw66RFNwQB1xivCojoqxGNfofgUe_bABW7gMUuYDEGHOnntyfbs38TjcDLEVgZ28or8x-1ZyOMEUEt9zDjVVXQWF-MdWm86Y24cIO30XixiCoFZDSntLpWjJpxq2g0k8Z_dvfCeFw1CBqf-wdiYs1n</recordid><startdate>20120101</startdate><enddate>20120101</enddate><creator>Taverna, Gianluigi</creator><creator>Benecchi, Luigi</creator><creator>Grizzi, Fabio</creator><creator>Seveso, Mauro</creator><creator>Giusti, Guido</creator><creator>Piccinelli, Alessandro</creator><creator>Benetti, Alessio</creator><creator>Colombo, Piergiuseppe</creator><creator>Minuti, Francesco</creator><creator>Graziotti, Pierpaolo</creator><general>Hindawi Limiteds</general><general>Hindawi Puplishing Corporation</general><general>Hindawi Publishing Corporation</general><scope>188</scope><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20120101</creationdate><title>Can a Gleason 6 or Less Microfocus of Prostate Cancer in One Biopsy and Prostate-Specific Antigen Level ＜10 ng/mL Be Defined as the Archetype of Low-Risk Prostate Disease?</title><author>Taverna, Gianluigi ; Benecchi, Luigi ; Grizzi, Fabio ; Seveso, Mauro ; Giusti, Guido ; Piccinelli, Alessandro ; Benetti, Alessio ; Colombo, Piergiuseppe ; Minuti, Francesco ; Graziotti, Pierpaolo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a441t-6cda11f1a7303aff841819b86e49478b215bc6e9ef7358221a012501d201bc8f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Taverna, Gianluigi</creatorcontrib><creatorcontrib>Benecchi, Luigi</creatorcontrib><creatorcontrib>Grizzi, Fabio</creatorcontrib><creatorcontrib>Seveso, Mauro</creatorcontrib><creatorcontrib>Giusti, Guido</creatorcontrib><creatorcontrib>Piccinelli, Alessandro</creatorcontrib><creatorcontrib>Benetti, Alessio</creatorcontrib><creatorcontrib>Colombo, Piergiuseppe</creatorcontrib><creatorcontrib>Minuti, Francesco</creatorcontrib><creatorcontrib>Graziotti, Pierpaolo</creatorcontrib><collection>Airiti Library</collection><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Taverna, Gianluigi</au><au>Benecchi, Luigi</au><au>Grizzi, Fabio</au><au>Seveso, Mauro</au><au>Giusti, Guido</au><au>Piccinelli, Alessandro</au><au>Benetti, Alessio</au><au>Colombo, Piergiuseppe</au><au>Minuti, Francesco</au><au>Graziotti, Pierpaolo</au><au>Roach, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Can a Gleason 6 or Less Microfocus of Prostate Cancer in One Biopsy and Prostate-Specific Antigen Level ＜10 ng/mL Be Defined as the Archetype of Low-Risk Prostate Disease?</atitle><jtitle>Journal of Oncology</jtitle><addtitle>J Oncol</addtitle><date>2012-01-01</date><risdate>2012</risdate><volume>2012</volume><issue>2012</issue><spage>486</spage><epage>491-051</epage><pages>486-491-051</pages><issn>1687-8450</issn><eissn>1687-8450</eissn><abstract>Prostate cancer (PC) remains a cause of death worldwide. Here we investigate whether a single microfocus of PC at the biopsy (graded as Gleason 6 or less, ≤5% occupancy) and the PSA <10 ng/mL can define the archetype of low-risk prostate disease. 4500 consecutive patients were enrolled. Among them, 134 patients with a single micro-focus of PC were followed up, and the parameters influencing the biochemical relapse (BR) were analysed. Out of 134 patients, 94 had clinically significant disease, specifically in 74.26% of the patients with PSA <10 ng/mL. Positive surgical margins and the extracapsular invasion were found in 29.1% and 51.4% patients, respectively. BR was observed in 29.6% of the patients. Cox regression evidenced a correlation between the BR and Gleason grade at the retropubic radical prostatectomy (RRP), capsular invasion, and the presence of positive surgical margins. Multivariate regression analysis showed a statistically significant correlation between the presence of surgical margins at the RRP and BR. Considering a single micro-focus of PC at the biopsy and PSA serum level <10 ng/mL, clinically significant disease was found in 74.26% patients and only positive surgical margins are useful for predicting the BR.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Limiteds</pub><pmid>22848218</pmid><doi>10.1155/2012/645146</doi><oa>free_for_read</oa></addata></record> |
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| title | Can a Gleason 6 or Less Microfocus of Prostate Cancer in One Biopsy and Prostate-Specific Antigen Level ＜10 ng/mL Be Defined as the Archetype of Low-Risk Prostate Disease? |
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