Mycobacterium tuberculosis Rv0652 stimulates production of tumour necrosis factor and monocytes chemoattractant protein‐1 in macrophages through the Toll‐like receptor 4 pathway

Summary Mycobacterial proteins interact with host macrophages and modulate their functions and cytokine gene expression profile. The protein Rv0652 is abundant in culture filtrates of Mycobacterium tuberculosis K‐strain, which belongs to the Beijing family, compared with levels in the H37Rv and CDC1...

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Veröffentlicht in:	Immunology 2012-06, Vol.136 (2), p.231-240
Hauptverfasser:	Kim, Kwangwook, Sohn, Hosung, Kim, Jong‐Seok, Choi, Han‐Gyu, Byun, Eui‐Hong, Lee, Kang‐In, Shin, Sung Jae, Song, Chang‐Hwa, Park, Jeong‐Kyu, Kim, Hwa‐Jung
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B7-1 Antigen - biosynthesis B7-1 Antigen - immunology B7-2 Antigen - biosynthesis B7-2 Antigen - immunology Bacterial Proteins - immunology Cell Line Chemokine CCL2 - biosynthesis Chemokine CCL2 - immunology cytokines Genes, MHC Class II - immunology Lectins, C-Type - biosynthesis Lectins, C-Type - immunology macrophage Macrophage Activation - drug effects Macrophage Activation - immunology Macrophages - immunology Macrophages - metabolism Macrophages - microbiology Male Mannose-Binding Lectins - biosynthesis Mannose-Binding Lectins - immunology MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - immunology Mice Mice, Inbred C57BL Mycobacterium tuberculosis Mycobacterium tuberculosis - immunology Myeloid Differentiation Factor 88 - antagonists & inhibitors Myeloid Differentiation Factor 88 - immunology NF-kappa B - antagonists & inhibitors NF-kappa B - immunology Original Receptors, Cell Surface - biosynthesis Receptors, Cell Surface - immunology Rv0652 signalling Toll-Like Receptor 4 - immunology Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - immunology
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