HER2 expression in renal cell carcinoma is rare and negatively correlated with that in normal renal tissue

HER2 expression in renal cell carcinoma is rare and negatively correlated with that in normal renal tissue

The aim of this study was to evaluate the status of HER2 protein expression in patients with renal cell carcinoma (RCC) and to determine its prognostic significance. A total of 42 paraffin-embedded tumor tissues and 42 additional corresponding adjacent normal tissues from RCC patients were randomly...

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Veröffentlicht in:Oncology letters 2012-08, Vol.4 (2), p.194-198
Hauptverfasser: WANG, HUILI, LIU, CHENGYI, HAN, JUN, ZHEN, LIN, ZHANG, TAO, HE, XIAOLI, XU, ENCI, LI, MENGQIANG
Format: Artikel
Sprache:eng
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Breast cancer
HER2
Kidney cancer
Kinases
Multivariate analysis
Oncology
Proteins
renal cell carcinoma
Signal transduction
Surgery
TNM stage
Tumors
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container_end_page 198
container_issue 2
container_start_page 194
container_title Oncology letters
container_volume 4
creator WANG, HUILI
LIU, CHENGYI
HAN, JUN
ZHEN, LIN
ZHANG, TAO
HE, XIAOLI
XU, ENCI
LI, MENGQIANG
description The aim of this study was to evaluate the status of HER2 protein expression in patients with renal cell carcinoma (RCC) and to determine its prognostic significance. A total of 42 paraffin-embedded tumor tissues and 42 additional corresponding adjacent normal tissues from RCC patients were randomly collected and studied using immunohistochemistry (IHC). Protein samples of 6 fresh specimens from tumor and adjacent normal tissues obtained during surgery were extracted and tested using western blotting to confirm the IHC results. Of the 42 tumor tissues and adjacent normal tissues tested, IHC showed that 7 tumors (16.67%) and 33 adjacent normal tissues (78.57%) expressed the HER2 protein. In addition, results of the western blotting revealed weak HER2 reactivity in primary tumor cells in two of 6 specimens obtained during surgery. All 6 normal tissues showed positive expression, which was in accordance with the outcome of IHC. In conclusion, HER2 is frequently expressed in normal renal tissues and rarely expressed in RCC tissues. Furthermore, the HER2 status of normal tissue is negatively correlated with that of the RCC tissues (r=−0.410, P=0.007) and the TNM stage (r=−0.246, P=0.027), suggesting that HER2 is involved in RCC oncogenesis.
doi_str_mv 10.3892/ol.2012.727
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A total of 42 paraffin-embedded tumor tissues and 42 additional corresponding adjacent normal tissues from RCC patients were randomly collected and studied using immunohistochemistry (IHC). Protein samples of 6 fresh specimens from tumor and adjacent normal tissues obtained during surgery were extracted and tested using western blotting to confirm the IHC results. Of the 42 tumor tissues and adjacent normal tissues tested, IHC showed that 7 tumors (16.67%) and 33 adjacent normal tissues (78.57%) expressed the HER2 protein. In addition, results of the western blotting revealed weak HER2 reactivity in primary tumor cells in two of 6 specimens obtained during surgery. All 6 normal tissues showed positive expression, which was in accordance with the outcome of IHC. In conclusion, HER2 is frequently expressed in normal renal tissues and rarely expressed in RCC tissues. 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Spandidos</publisher><subject>Breast cancer ; HER2 ; Kidney cancer ; Kinases ; Multivariate analysis ; Oncology ; Proteins ; renal cell carcinoma ; Signal transduction ; Surgery ; TNM stage ; Tumors</subject><ispartof>Oncology letters, 2012-08, Vol.4 (2), p.194-198</ispartof><rights>Copyright © 2012, Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2012</rights><rights>Copyright © 2012, Spandidos Publications 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-e482eea2ef08357297c076025d7569c155bcd80c11260d4c88bf6324c0bb0a5a3</citedby><cites>FETCH-LOGICAL-c440t-e482eea2ef08357297c076025d7569c155bcd80c11260d4c88bf6324c0bb0a5a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402757/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402757/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,5555,27903,27904,53770,53772</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22844352$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>WANG, HUILI</creatorcontrib><creatorcontrib>LIU, CHENGYI</creatorcontrib><creatorcontrib>HAN, JUN</creatorcontrib><creatorcontrib>ZHEN, LIN</creatorcontrib><creatorcontrib>ZHANG, TAO</creatorcontrib><creatorcontrib>HE, XIAOLI</creatorcontrib><creatorcontrib>XU, ENCI</creatorcontrib><creatorcontrib>LI, MENGQIANG</creatorcontrib><title>HER2 expression in renal cell carcinoma is rare and negatively correlated with that in normal renal tissue</title><title>Oncology letters</title><addtitle>Oncol Lett</addtitle><description>The aim of this study was to evaluate the status of HER2 protein expression in patients with renal cell carcinoma (RCC) and to determine its prognostic significance. 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source Spandidos Publications Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central
subjects Breast cancer
HER2
Kidney cancer
Kinases
Multivariate analysis
Oncology
Proteins
renal cell carcinoma
Signal transduction
Surgery
TNM stage
Tumors
title HER2 expression in renal cell carcinoma is rare and negatively correlated with that in normal renal tissue
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