Chinese hamster ovary cell lines selected for resistance to ebolavirus glycoprotein mediated infection are defective for NPC1 expression

Abstract Ebolavirus causes severe hemorrhagic fever in humans and non-human primates. Entry of ebolavirus is mediated by the viral glycoprotein, GP; however, the required host factors have not been fully elucidated. A screen utilizing a recombinant Vesicular Stomatitis Virus (VSV) encoding Zaire ebo...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2012-10, Vol.432 (1), p.20-28
Hauptverfasser:	Haines, Kathleen M, Vande Burgt, Nathan H, Francica, Joseph R, Kaletsky, Rachel L, Bates, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CHO Cells CHO-K1 Cricetinae Cricetulus Ebolavirus Ebolavirus - pathogenicity Ebolavirus - physiology Ebolavirus GP Genetic Complementation Test Host factor Host-Pathogen Interactions Infectious Disease Membrane Glycoproteins - biosynthesis Membrane Glycoproteins - deficiency Mutation Niemann–Pick Type C1—NPC1 Receptors, Virus - biosynthesis Receptors, Virus - deficiency Viral entry Viral glycoprotein Virus Internalization
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!