Granzyme B: Evidence for a role in the origin of myasthenia gravis

Abstract Purpose of research Although the pathogenesis of myasthenia gravis (MG) as an antibody mediated disorder of acetylcholine receptors (AChRs) at neuromuscular junctions is well understood, the origin of the autoimmune response is unclear. The thymus is intimately involved in initiation of the...

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Veröffentlicht in:	Journal of neuroimmunology 2008-09, Vol.201, p.33-40
Hauptverfasser:	Casciola-Rosen, L, Miagkov, A, Nagaraju, K, Askin, F, Jacobson, L, Rosen, A, Drachman, D.B
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine receptor Allergy and Immunology Autoimmunity Cell Line Epsilon subunit Gene Expression - drug effects Gene Expression - physiology Granzyme B Granzymes - genetics Granzymes - metabolism Granzymes - pharmacology Humans Methionine - metabolism Myasthenia gravis Myasthenia Gravis - pathology Neurology Receptors, Cholinergic - classification Receptors, Cholinergic - genetics Receptors, Cholinergic - metabolism Receptors, Nicotinic Sulfur Isotopes - metabolism Thymus Thymus Gland - drug effects Thymus Gland - metabolism Transfection
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