A Novel Anti-inflammatory Role for Spleen-Derived Interleukin-10 in Obesity-Induced Inflammation in White Adipose Tissue and Liver

Obesity is associated with systemic low-grade inflammation and obesity-related metabolic disorders. Considering that obesity decreases the expression of proinflammatory cytokines in the spleen, we assessed the role of interleukin (IL)-10, an anti-inflammatory cytokine produced by the spleen, in the...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2012-08, Vol.61 (8), p.1994-2003
Hauptverfasser:	GOTOH, Koro, INOUE, Megumi, SAKATA, Toshiie, YOSHIMATSU, Hironobu, MASAKI, Takayuki, CHIBA, Seiichi, SHIMASAKI, Takanobu, ANDO, Hisae, FUJIWARA, Kansuke, KATSURAGI, Isao, KAKUMA, Tetsuya, SEIKE, Masataka
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdomen Adipose Tissue, White - metabolism Adipose Tissue, White - pathology Adipose tissues Animals Antibodies Biological and medical sciences Body fat Care and treatment Complications and side effects Cytokines Diabetes. Impaired glucose tolerance Diet, High-Fat Eating Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Experiments Fatty acids Food Genetic aspects Hepatitis - etiology Inflammation Inflammation - etiology Inflammation - metabolism Interleukin-10 Interleukin-10 - blood Interleukin-10 - physiology Laboratory animals Lipid Metabolism Liver Male Medical sciences Metabolic diseases Mice Mice, Knockout Obesity Obesity - complications Obesity Studies Pathogenesis Physiological aspects Proteins Risk factors Spleen Spleen - metabolism Splenectomy Tumor necrosis factor-TNF
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