Deregulation of FoxM1b leads to tumour metastasis

The forkhead box M1b (FoxM1b) transcription factor is over‐expressed in human cancers, and its expression often correlates with poor prognosis. Previously, using conditional knockout strains, we showed that FoxM1b is essential for hepatocellular carcinoma (HCC) development. However, over‐expression...

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Veröffentlicht in:	EMBO molecular medicine 2011-01, Vol.3 (1), p.21-34
Hauptverfasser:	Park, Hyun Jung, Gusarova, Galina, Wang, Zebin, Carr, Janai R., Li, Jing, Kim, Ki‐Hyun, Qiu, Jin, Park, Yoon‐Dong, Williamson, Peter R., Hay, Nissim, Tyner, Angela L., Lau, Lester F., Costa, Robert H., Raychaudhuri, Pradip
Format:	Artikel
Sprache:	eng
Schlagworte:	ADP-Ribosylation Factors - genetics ADP-Ribosylation Factors - metabolism AKT protein Animals Arf Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - secondary Cell adhesion & migration Cell cycle Collagen Epithelial-Mesenchymal Transition Experiments Fibrosis Forkhead Box Protein M1 Forkhead protein Forkhead Transcription Factors - antagonists & inhibitors Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism FoxM1 Gene expression Hepatocellular carcinoma Humans Liver cancer Liver Cirrhosis - metabolism Liver Cirrhosis - pathology Liver Neoplasms - metabolism Liver Neoplasms - pathology Lungs Lysyl oxidase Mesenchyme Metastases Metastasis Mice Mice, Transgenic Neoplasm Metastasis Peptides Plasmids Protein-Lysine 6-Oxidase - metabolism Proto-Oncogene Proteins c-akt - metabolism Research Article Signal Transduction Snail Family Transcription Factors Stathmin Stathmin - metabolism Transcription factors Transcription Factors - metabolism Tumors
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