Formation of duodenal atresias in fibroblast growth factor receptor 2IIIb−/− mouse embryos occurs in the absence of an endodermal plug

Abstract Purpose Duodenal atresia in humans has been hypothesized to arise from a failure of the duodenal lumen to recanalize after formation of an endodermal plug. Recently, mutations in the fibroblast growth factor receptor 2 gene ( Fgfr2IIIb ) have been shown to cause atretic defects of the duode...

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Veröffentlicht in:	Journal of pediatric surgery 2012-07, Vol.47 (7), p.1369-1379
Hauptverfasser:	Botham, Robert A, Franco, Marta, Reeder, Amy L, Lopukhin, Anastasia, Shiota, Kohei, Yamada, Shigehito, Nichol, Peter F
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberrant morphogenesis Animals Apoptosis Apoptosis - genetics Disease Models, Animal Duodenal atresia Duodenal Obstruction - embryology Duodenal Obstruction - genetics Duodenum - embryology Endoderm - embryology Fgfr2IIIb Genetic Markers Humans Immunohistochemistry In Situ Nick-End Labeling Mice - embryology Mice - genetics Mice, Knockout Mouse Pediatrics Receptor, Fibroblast Growth Factor, Type 2 - genetics Surgery
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