Formation of the Thiol Conjugates and Active Metabolite of Clopidogrel by Human Liver Microsomes

We reported previously the formation of a glutathionyl conjugate of the active metabolite (AM) of clopidogrel and the covalent modification of a cysteinyl residue of human cytochrome P450 2B6 in a reconstituted system (Mol Pharmacol80:839–847, 2011). In this work, we extended our studies of the meta...

Ausführliche Beschreibung