Ligand bias at metabotropic glutamate 1a receptors: molecular determinants that distinguish β-arrestin-mediated from G protein-mediated signaling

The metabotropic glutamate 1a (mGlu1a) receptor is a G protein-coupled receptor linked with phosphoinositide (PI) hydrolysis and with β-arrestin-1-mediated sustained extracellular signal-regulated kinase (ERK) phosphorylation and cytoprotective signaling. Previously, we reported the existence of lig...

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Veröffentlicht in:	Molecular pharmacology 2012-08, Vol.82 (2), p.291-301
Hauptverfasser:	Emery, Andrew C, DiRaddo, John O, Miller, Eric, Hathaway, Hannah A, Pshenichkin, Sergey, Takoudjou, Guy Rodrigue, Grajkowska, Ewa, Yasuda, Robert P, Wolfe, Barry B, Wroblewski, Jarda T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arrestins - physiology beta-Arrestins Cells, Cultured CHO Cells Cricetinae Cricetulus Dose-Response Relationship, Drug Ligands Receptors, G-Protein-Coupled - physiology Receptors, Metabotropic Glutamate - metabolism Signal Transduction - physiology
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