Mechanism for Calcium Ion Sensing by the C2A Domain of Synaptotagmin I

The C2A domain is one of two calcium ion (Ca2+)- and membrane-binding domains within synaptotagmin I (Syt I), the identified Ca2+ sensor for regulated exocytosis of neurotransmitter. We propose that the mechanistic basis for C2A's response to Ca2+ and cellular function stems from marginal stabi...

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Veröffentlicht in:	Biophysical journal 2012-07, Vol.103 (2), p.238-246
Hauptverfasser:	Gauer, Jacob W., Sisk, Ryan, Murphy, Jesse R., Jacobson, Heathere, Sutton, R. Bryan, Gillispie, Gregory D., Hinderliter, Anne
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding sites Biological Assay Calcium Calcium - metabolism denaturation Differential scanning calorimetry energy transfer exocytosis Fluoresceins - metabolism Fluorescence functional response Humans Ions Membrane Membranes Protein Binding Protein Denaturation Protein Structure, Tertiary Proteins spectroscopy Structure-Activity Relationship Synaptotagmin I - chemistry Synaptotagmin I - metabolism Thermodynamics
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