Polycomb group protein EZH2-mediated E-cadherin repression promotes metastasis of oral tongue squamous cell carcinoma
Enhancer of Zeste homolog 2 (EZH2) is a critical component of the polycomb‐repressive complex 2 (PRC2) that regulates many essential biological processes, including embryogenesis and many developmental events. The oncogenic role of EZH2 has recently been implicated in several cancer types. In this s...
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| Veröffentlicht in: | Molecular carcinogenesis 2013-03, Vol.52 (3), p.229-236 |
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| container_title | Molecular carcinogenesis |
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| creator | Wang, Cheng Liu, Xiqiang Chen, Zujian Huang, Hongzhang Jin, Yi Kolokythas, Antonia Wang, Anxun Dai, Yang Wong, David T.W. Zhou, Xiaofeng |
| description | Enhancer of Zeste homolog 2 (EZH2) is a critical component of the polycomb‐repressive complex 2 (PRC2) that regulates many essential biological processes, including embryogenesis and many developmental events. The oncogenic role of EZH2 has recently been implicated in several cancer types. In this study, we first confirmed that the over‐expression of EZH2 is a frequent event in oral tongue squamous cell carcinoma (OTSCC). We further demonstrated that EZH2 over‐expression is correlated with advanced stages of the disease and is associated with lymph node metastasis. Statistical analysis revealed that EZH2 over‐expression was correlated with reduced overall survival. Furthermore, over‐expression of EZH2 was correlated with reduced expression of tumor suppressor gene E‐cadherin. These observations were confirmed in vitro, in which knockdown of EZH2‐induced E‐cadherin expression and reduced cell migration and invasion. In contrast, ectopic transfection of EZH2 led to reduced E‐cadherin expression and enhanced cell migration and invasion. Furthermore, EZH2 may act on cell migration in part by suppressing the E‐cadherin expression. Taken together, these data suggest that EZH2 plays major roles in the progression of OTSCC, and may serve as a biomarker or therapeutic target for patients at risk of metastasis. © 2011 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/mc.21848 |
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The oncogenic role of EZH2 has recently been implicated in several cancer types. In this study, we first confirmed that the over‐expression of EZH2 is a frequent event in oral tongue squamous cell carcinoma (OTSCC). We further demonstrated that EZH2 over‐expression is correlated with advanced stages of the disease and is associated with lymph node metastasis. Statistical analysis revealed that EZH2 over‐expression was correlated with reduced overall survival. Furthermore, over‐expression of EZH2 was correlated with reduced expression of tumor suppressor gene E‐cadherin. These observations were confirmed in vitro, in which knockdown of EZH2‐induced E‐cadherin expression and reduced cell migration and invasion. In contrast, ectopic transfection of EZH2 led to reduced E‐cadherin expression and enhanced cell migration and invasion. Furthermore, EZH2 may act on cell migration in part by suppressing the E‐cadherin expression. Taken together, these data suggest that EZH2 plays major roles in the progression of OTSCC, and may serve as a biomarker or therapeutic target for patients at risk of metastasis. © 2011 Wiley Periodicals, Inc.</description><identifier>ISSN: 0899-1987</identifier><identifier>EISSN: 1098-2744</identifier><identifier>DOI: 10.1002/mc.21848</identifier><identifier>PMID: 22161744</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Biomarkers ; Cadherins - genetics ; Cadherins - metabolism ; Carcinoma, Squamous Cell - metabolism ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - pathology ; Cell Line, Tumor ; Cell Movement ; E-cadherin ; Enhancer of Zeste Homolog 2 Protein ; EZH2 ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Lymphatic Metastasis ; Male ; Metastasis ; Oral cancer ; Polycomb Repressive Complex 2 - genetics ; Polycomb Repressive Complex 2 - metabolism ; Prognosis ; Proteins ; squamous cell carcinoma ; Tongue Neoplasms - metabolism ; Tongue Neoplasms - mortality ; Tongue Neoplasms - pathology</subject><ispartof>Molecular carcinogenesis, 2013-03, Vol.52 (3), p.229-236</ispartof><rights>Copyright © 2011 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5428-98f91772c7ea09c4c9282010b5c8d1921c6073a17576bdf94a0fed7701ece66a3</citedby><cites>FETCH-LOGICAL-c5428-98f91772c7ea09c4c9282010b5c8d1921c6073a17576bdf94a0fed7701ece66a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmc.21848$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmc.21848$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22161744$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Cheng</creatorcontrib><creatorcontrib>Liu, Xiqiang</creatorcontrib><creatorcontrib>Chen, Zujian</creatorcontrib><creatorcontrib>Huang, Hongzhang</creatorcontrib><creatorcontrib>Jin, Yi</creatorcontrib><creatorcontrib>Kolokythas, Antonia</creatorcontrib><creatorcontrib>Wang, Anxun</creatorcontrib><creatorcontrib>Dai, Yang</creatorcontrib><creatorcontrib>Wong, David T.W.</creatorcontrib><creatorcontrib>Zhou, Xiaofeng</creatorcontrib><title>Polycomb group protein EZH2-mediated E-cadherin repression promotes metastasis of oral tongue squamous cell carcinoma</title><title>Molecular carcinogenesis</title><addtitle>Mol. Carcinog</addtitle><description>Enhancer of Zeste homolog 2 (EZH2) is a critical component of the polycomb‐repressive complex 2 (PRC2) that regulates many essential biological processes, including embryogenesis and many developmental events. The oncogenic role of EZH2 has recently been implicated in several cancer types. In this study, we first confirmed that the over‐expression of EZH2 is a frequent event in oral tongue squamous cell carcinoma (OTSCC). We further demonstrated that EZH2 over‐expression is correlated with advanced stages of the disease and is associated with lymph node metastasis. Statistical analysis revealed that EZH2 over‐expression was correlated with reduced overall survival. Furthermore, over‐expression of EZH2 was correlated with reduced expression of tumor suppressor gene E‐cadherin. These observations were confirmed in vitro, in which knockdown of EZH2‐induced E‐cadherin expression and reduced cell migration and invasion. In contrast, ectopic transfection of EZH2 led to reduced E‐cadherin expression and enhanced cell migration and invasion. Furthermore, EZH2 may act on cell migration in part by suppressing the E‐cadherin expression. Taken together, these data suggest that EZH2 plays major roles in the progression of OTSCC, and may serve as a biomarker or therapeutic target for patients at risk of metastasis. © 2011 Wiley Periodicals, Inc.</description><subject>Biomarkers</subject><subject>Cadherins - genetics</subject><subject>Cadherins - metabolism</subject><subject>Carcinoma, Squamous Cell - metabolism</subject><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Cell Line, Tumor</subject><subject>Cell Movement</subject><subject>E-cadherin</subject><subject>Enhancer of Zeste Homolog 2 Protein</subject><subject>EZH2</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Metastasis</subject><subject>Oral cancer</subject><subject>Polycomb Repressive Complex 2 - genetics</subject><subject>Polycomb Repressive Complex 2 - metabolism</subject><subject>Prognosis</subject><subject>Proteins</subject><subject>squamous cell carcinoma</subject><subject>Tongue Neoplasms - metabolism</subject><subject>Tongue Neoplasms - mortality</subject><subject>Tongue Neoplasms - pathology</subject><issn>0899-1987</issn><issn>1098-2744</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kV1rFDEYhYModlsFf4EEvOnN1CSTmSQ3gixrW_qhgiJ4E7KZd7apk8k0mbHuvzfbbrcqCIFcvA8P53AQekXJESWEvfX2iFHJ5RM0o0TJggnOn6IZkUoVVEmxh_ZTuiaEUlGR52iPMVrTzMzQ9Cl0axv8Eq9imAY8xDCC6_Hi-wkrPDTOjNDgRWFNcwUxHyIMEVJyod-wPtMJexhNys8lHFocounwGPrVBDjdTMaHKWELXYetidb1wZsX6FlrugQvt_8B-vph8WV-Upx_PD6dvz8vbMWZLJRsFRWCWQGGKMutYpIRSpaVlQ1VjNqaiNLkUqJeNq3ihrTQCEEoWKhrUx6gd_feYVrmMhb6MYfTQ3TexLUOxum_L7270qvwU5ecEEHLLDjcCmK4mSCN2ru06WJ6yLU0ZZIzRVi1Qd_8g16HKfa5nqac51lUrcSj0MaQUoR2F4YSvdlSe6vvtszo6z_D78CH8TJQ3AO3roP1f0X6Yv4g3PIujfBrx5v4Q9eiFJX-dnms5dnF55qdVZqVvwFHOLgg</recordid><startdate>201303</startdate><enddate>201303</enddate><creator>Wang, Cheng</creator><creator>Liu, Xiqiang</creator><creator>Chen, Zujian</creator><creator>Huang, Hongzhang</creator><creator>Jin, Yi</creator><creator>Kolokythas, Antonia</creator><creator>Wang, Anxun</creator><creator>Dai, Yang</creator><creator>Wong, David T.W.</creator><creator>Zhou, Xiaofeng</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7TO</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201303</creationdate><title>Polycomb group protein EZH2-mediated E-cadherin repression promotes metastasis of oral tongue squamous cell carcinoma</title><author>Wang, Cheng ; Liu, Xiqiang ; Chen, Zujian ; Huang, Hongzhang ; Jin, Yi ; Kolokythas, Antonia ; Wang, Anxun ; Dai, Yang ; Wong, David T.W. ; Zhou, Xiaofeng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5428-98f91772c7ea09c4c9282010b5c8d1921c6073a17576bdf94a0fed7701ece66a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Biomarkers</topic><topic>Cadherins - genetics</topic><topic>Cadherins - metabolism</topic><topic>Carcinoma, Squamous Cell - metabolism</topic><topic>Carcinoma, Squamous Cell - mortality</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Cell Line, Tumor</topic><topic>Cell Movement</topic><topic>E-cadherin</topic><topic>Enhancer of Zeste Homolog 2 Protein</topic><topic>EZH2</topic><topic>Female</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Metastasis</topic><topic>Oral cancer</topic><topic>Polycomb Repressive Complex 2 - genetics</topic><topic>Polycomb Repressive Complex 2 - metabolism</topic><topic>Prognosis</topic><topic>Proteins</topic><topic>squamous cell carcinoma</topic><topic>Tongue Neoplasms - metabolism</topic><topic>Tongue Neoplasms - mortality</topic><topic>Tongue Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Cheng</creatorcontrib><creatorcontrib>Liu, Xiqiang</creatorcontrib><creatorcontrib>Chen, Zujian</creatorcontrib><creatorcontrib>Huang, Hongzhang</creatorcontrib><creatorcontrib>Jin, Yi</creatorcontrib><creatorcontrib>Kolokythas, Antonia</creatorcontrib><creatorcontrib>Wang, Anxun</creatorcontrib><creatorcontrib>Dai, Yang</creatorcontrib><creatorcontrib>Wong, David T.W.</creatorcontrib><creatorcontrib>Zhou, Xiaofeng</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Molecular carcinogenesis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Cheng</au><au>Liu, Xiqiang</au><au>Chen, Zujian</au><au>Huang, Hongzhang</au><au>Jin, Yi</au><au>Kolokythas, Antonia</au><au>Wang, Anxun</au><au>Dai, Yang</au><au>Wong, David T.W.</au><au>Zhou, Xiaofeng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polycomb group protein EZH2-mediated E-cadherin repression promotes metastasis of oral tongue squamous cell carcinoma</atitle><jtitle>Molecular carcinogenesis</jtitle><addtitle>Mol. Carcinog</addtitle><date>2013-03</date><risdate>2013</risdate><volume>52</volume><issue>3</issue><spage>229</spage><epage>236</epage><pages>229-236</pages><issn>0899-1987</issn><eissn>1098-2744</eissn><abstract>Enhancer of Zeste homolog 2 (EZH2) is a critical component of the polycomb‐repressive complex 2 (PRC2) that regulates many essential biological processes, including embryogenesis and many developmental events. The oncogenic role of EZH2 has recently been implicated in several cancer types. In this study, we first confirmed that the over‐expression of EZH2 is a frequent event in oral tongue squamous cell carcinoma (OTSCC). We further demonstrated that EZH2 over‐expression is correlated with advanced stages of the disease and is associated with lymph node metastasis. Statistical analysis revealed that EZH2 over‐expression was correlated with reduced overall survival. Furthermore, over‐expression of EZH2 was correlated with reduced expression of tumor suppressor gene E‐cadherin. These observations were confirmed in vitro, in which knockdown of EZH2‐induced E‐cadherin expression and reduced cell migration and invasion. In contrast, ectopic transfection of EZH2 led to reduced E‐cadherin expression and enhanced cell migration and invasion. Furthermore, EZH2 may act on cell migration in part by suppressing the E‐cadherin expression. Taken together, these data suggest that EZH2 plays major roles in the progression of OTSCC, and may serve as a biomarker or therapeutic target for patients at risk of metastasis. © 2011 Wiley Periodicals, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>22161744</pmid><doi>10.1002/mc.21848</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Molecular carcinogenesis, 2013-03, Vol.52 (3), p.229-236 |
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| subjects | Biomarkers Cadherins - genetics Cadherins - metabolism Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - pathology Cell Line, Tumor Cell Movement E-cadherin Enhancer of Zeste Homolog 2 Protein EZH2 Female Gene Expression Regulation, Neoplastic Humans Lymphatic Metastasis Male Metastasis Oral cancer Polycomb Repressive Complex 2 - genetics Polycomb Repressive Complex 2 - metabolism Prognosis Proteins squamous cell carcinoma Tongue Neoplasms - metabolism Tongue Neoplasms - mortality Tongue Neoplasms - pathology |
| title | Polycomb group protein EZH2-mediated E-cadherin repression promotes metastasis of oral tongue squamous cell carcinoma |
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