Developmental triclosan exposure decreases maternal, fetal, and early neonatal thyroxine: A dynamic and kinetic evaluation of a putative mode-of-action

This work tests the mode-of-action (MOA) hypothesis that maternal and developmental triclosan (TCS) exposure decreases circulating thyroxine (T4) concentrations via up-regulation of hepatic catabolism and elimination of T4. Time-pregnant Long-Evans rats received TCS po (0–300mg/kg/day) from gestatio...

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Veröffentlicht in:	Toxicology (Amsterdam) 2012-10, Vol.300 (1-2), p.31-45
Hauptverfasser:	Paul, Katie B, Hedge, Joan M, Bansal, Ruby, Zoeller, R. Thomas, Peter, Robert, DeVito, Michael J, Crofton, Kevin M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn - blood Animals, Newborn - metabolism Biological and medical sciences blood serum cytochrome P-450 Cytochrome P-450 CYP1A1 - drug effects Cytochrome P-450 CYP1A1 - metabolism Cytochrome P-450 CYP2B1 - drug effects Cytochrome P-450 CYP2B1 - metabolism Developmental exposure Emergency enzyme activity Female fetus Fetus - chemistry Fetus - drug effects gene expression genes Glucuronosyltransferase - drug effects Glucuronosyltransferase - metabolism hormone metabolism liver Liver - drug effects Liver - enzymology liver microsomes Medical sciences messenger RNA Mode-of-action neonates Pregnancy progeny pups quantitative polymerase chain reaction Radioimmunoassay radioimmunoassays Rats Rats, Long-Evans sulfotransferases Thyroid disruption thyrotropin Thyrotropin - blood Thyroxine - antagonists & inhibitors Thyroxine - blood Toxicology transporters Triclosan Triclosan - adverse effects Triclosan - analysis Triclosan - blood triiodothyronine Triiodothyronine - blood uridine diphosphate
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