The oxidative DNA lesions 8,5′‐cyclopurines accumulate with aging in a tissue‐specific manner

Summary Accumulation of DNA damage is implicated in aging. This is supported by the fact that inherited defects in DNA repair can cause accelerated aging of tissues. However, clear‐cut evidence for DNA damage accumulation in old age is lacking. Numerous studies report measurement of DNA damage in nu...

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Veröffentlicht in:	Aging cell 2012-08, Vol.11 (4), p.714-716
Hauptverfasser:	Wang, Jin, Clauson, Cheryl L., Robbins, Paul D., Niedernhofer, Laura J., Wang, Yinsheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging - genetics Aging - metabolism Aging, Premature - genetics Aging, Premature - metabolism Animals Brain - metabolism Deoxyribonucleic acid DNA DNA Damage DNA Repair DNA-Binding Proteins - deficiency DNA-Binding Proteins - genetics Endonucleases - deficiency Endonucleases - genetics Female Kidney - metabolism Liver - metabolism Male Mice Mice, Congenic Mice, Knockout Mitochondrial DNA nucleotide excision repair oxidative DNA lesion progeria Purines - metabolism
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