Rate of degradation of [α]- and [β]-oligodeoxynucleotides in Xenopus oocytes. Implications for anti-messenger strategies

End-labelled oligodeoxynucleotides were injected into Xenopus laevis oocytes and their degradation products were analysed by high-performance ion-exchange liquid chromatography after various times of incubation. The oligonucleotides were synthesised with either the natural [beta] anomers or the synt...

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Veröffentlicht in:	Nucleic acids research 1987-12, Vol.15 (24), p.10507-10521
Hauptverfasser:	CAZENAVE, C, CHEVRIER, M, THUONG, N. T, HELENE, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Acridines Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Chromatography, High Pressure Liquid Dna, deoxyribonucleoproteins Fundamental and applied biological sciences. Psychology Microinjections Nucleic acids Oligodeoxyribonucleotides - metabolism Oocytes - metabolism RNA - metabolism RNA, Antisense Time Factors Xenopus laevis
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