LINE-1 Elements and X Chromosome Inactivation: A Function for "Junk" DNA?
X chromosome inactivation (XCI) is the mechanism used in mammals for dosage compensation of X-linked genes between chromosomally XX females and XY males. Lyon has proposed that LINE-1 elements (L1s) are "boosters" along the X chromosome that act as promoters of spreading.
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2000-06, Vol.97 (12), p.6248-6249 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
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| creator | Lyon, Mary F. |
| description | X chromosome inactivation (XCI) is the mechanism used in mammals for dosage compensation of X-linked genes between chromosomally XX females and XY males. Lyon has proposed that LINE-1 elements (L1s) are "boosters" along the X chromosome that act as promoters of spreading. |
| doi_str_mv | 10.1073/pnas.97.12.6248 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 2000-06, Vol.97 (12), p.6248-6249 |
| issn | 0027-8424 1091-6490 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_33995 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Autosomes Chromosomes Commentaries Deoxyribonucleic acid DNA Embryos Female Genes Genetics Human X chromosome Humans Repetitive Sequences, Nucleic Acid RNA Sex chromosomes X Chromosome X Chromosome inactivation |
| title | LINE-1 Elements and X Chromosome Inactivation: A Function for "Junk" DNA? |
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