Signal transducer and activator of transcription 3 is involved in the cardioprotective signalling pathway activated by insulin therapy at reperfusion

Objective To evaluate the significance of the JAK-STAT pathway in insulin-induced cardioprotection from reperfusion injury. Methods In isolated perfused rat hearts subjected to insulin therapy (0.3 mU/ml) ± AG490 (5 µM, JAK-STAT inhibitor), the phosphorylation state of STAT3 and Akt was determined a...

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Veröffentlicht in:	Basic research in cardiology 2008-09, Vol.103 (5), p.444-453
Hauptverfasser:	Fuglesteg, Britt N., Suleman, Naushaad, Tiron, Crina, Kanhema, Tambuzai, Lacerda, Lydia, Andreasen, Thomas V., Sack, Michael N., Jonassen, Anne K., Mjøs, Ole D., Opie, Lionel H., Lecour, Sandrine
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cardiology Cardiotonic Agents - pharmacology Cell Death - drug effects Cell Survival - drug effects Disease Models, Animal Enzyme Inhibitors - pharmacology Insulin - pharmacology Male Medicine Medicine & Public Health Mice Mice, Mutant Strains Myocardial Reperfusion Injury - drug therapy Myocardial Reperfusion Injury - metabolism Myocardial Reperfusion Injury - pathology Myocytes, Cardiac - cytology Myocytes, Cardiac - metabolism Original Contribution Oxygen - pharmacology Phosphorylation Proto-Oncogene Proteins c-akt - metabolism Rats Rats, Wistar Signal Transduction - physiology STAT3 Transcription Factor - antagonists & inhibitors STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism Tyrphostins - pharmacology
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