Dual-Mode Single-Molecule Fluorescence Assay for the Detection of Expanded CGG Repeats in Fragile X Syndrome

Fragile X syndrome is the leading cause of inherited mental impairment and is associated with expansions of CGG repeats within the FMR1 gene. To detect expanded CGG repeats, we developed a dual-mode single-molecule fluorescence assay that allows acquisition of two parallel, independent measures of r...

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Veröffentlicht in:	Molecular biotechnology 2013, Vol.53 (1), p.19-28
Hauptverfasser:	Cannon, Brian, Pan, Cynthia, Chen, Liangjing, Hadd, Andrew G, Russell, Rick
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biological Techniques Biotechnology Cell Biology Chemistry Chemistry and Materials Science DNA DNA - chemistry DNA - isolation & purification Fluorescence Fluorescent indicators fragile X mental retardation protein Fragile X Mental Retardation Protein - genetics Fragile X Mental Retardation Protein - metabolism Fragile X syndrome Fragile X Syndrome - diagnosis Fragile X Syndrome - genetics genes Genetic disorders Heterozygosity Heterozygote Human Genetics Humans Microscopy, Fluorescence - methods Molecular biology Mutation Protein Science Satellite DNA screening Trinucleotide Repeat Expansion
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