In vivo Imaging of Inflammation- and Tumor-Induced Lymph Node Lymphangiogenesis by Immuno―Positron Emission Tomography
Metastasis to regional lymph nodes (LN) is a prognostic indicator for cancer progression. There is a great demand for sensitive and noninvasive methods to detect metastasis to LNs. Whereas conventional in vivo imaging approaches have focused on the detection of cancer cells, lymphangiogenesis within...
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| Veröffentlicht in: | Cancer research (Chicago, Ill.) Ill.), 2010-11, Vol.70 (21), p.8842-8851 |
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| creator | MUMPRECHT, Viviane HONER, Michael VIGL, Benjamin PROULX, Steven T TRACHSEL, Eveline KASPAR, Manuela BANZIGER-TOBLER, Nadja E SCHIBLI, Roger NERI, Dario DETMAR, Michael |
| description | Metastasis to regional lymph nodes (LN) is a prognostic indicator for cancer progression. There is a great demand for sensitive and noninvasive methods to detect metastasis to LNs. Whereas conventional in vivo imaging approaches have focused on the detection of cancer cells, lymphangiogenesis within tumor-draining LNs might be the earliest sign of metastasis. In mouse models of LN lymphangiogenesis, we found that systemically injected antibodies to lymphatic epitopes accumulated in the lymphatic vasculature in tissues and LNs. Using a (124)I-labeled antibody against the lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1), we imaged, for the first time, inflammation- and tumor-draining LNs with expanded lymphatic networks in vivo by positron emission tomography (PET). Anti-LYVE-1 immuno-PET enabled visualization of lymphatic vessel expansion in LNs bearing metastases that were not detected by [(18)F]fluorodeoxyglucose-PET, which is clinically applied to detect cancer metastases. Immuno-PET with lymphatic-specific antibodies may open up new avenues for the early detection of metastasis, and the images obtained might be used as biomarkers for the progression of diseases associated with lymphangiogenesis. |
| doi_str_mv | 10.1158/0008-5472.can-10-0896 |
| format | Article |
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There is a great demand for sensitive and noninvasive methods to detect metastasis to LNs. Whereas conventional in vivo imaging approaches have focused on the detection of cancer cells, lymphangiogenesis within tumor-draining LNs might be the earliest sign of metastasis. In mouse models of LN lymphangiogenesis, we found that systemically injected antibodies to lymphatic epitopes accumulated in the lymphatic vasculature in tissues and LNs. Using a (124)I-labeled antibody against the lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1), we imaged, for the first time, inflammation- and tumor-draining LNs with expanded lymphatic networks in vivo by positron emission tomography (PET). Anti-LYVE-1 immuno-PET enabled visualization of lymphatic vessel expansion in LNs bearing metastases that were not detected by [(18)F]fluorodeoxyglucose-PET, which is clinically applied to detect cancer metastases. Immuno-PET with lymphatic-specific antibodies may open up new avenues for the early detection of metastasis, and the images obtained might be used as biomarkers for the progression of diseases associated with lymphangiogenesis.</description><identifier>ISSN: 0008-5472</identifier><identifier>EISSN: 1538-7445</identifier><identifier>DOI: 10.1158/0008-5472.can-10-0896</identifier><identifier>PMID: 20978206</identifier><identifier>CODEN: CNREA8</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Animals ; Antibodies, Monoclonal - immunology ; Antineoplastic agents ; Biological and medical sciences ; Diagnostic Imaging ; Female ; Fluorodeoxyglucose F18 ; Glycoproteins - immunology ; Humans ; Inflammation - complications ; Inflammation - immunology ; Inflammation - pathology ; Iodine Radioisotopes - pharmacokinetics ; Luminescent Measurements ; Lymph Nodes - diagnostic imaging ; Lymph Nodes - immunology ; Lymph Nodes - pathology ; Lymphangiogenesis ; Lymphatic Metastasis ; Medical sciences ; Melanoma, Experimental - complications ; Melanoma, Experimental - immunology ; Melanoma, Experimental - pathology ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Pharmacology. Drug treatments ; Positron-Emission Tomography ; Prognosis ; Radiopharmaceuticals ; Skin - metabolism ; Tissue Distribution ; Tumors ; Vascular Endothelial Growth Factor C - metabolism ; Vascular Endothelial Growth Factor Receptor-3 - immunology</subject><ispartof>Cancer research (Chicago, Ill.), 2010-11, Vol.70 (21), p.8842-8851</ispartof><rights>2015 INIST-CNRS</rights><rights>2010 AACR.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c506t-db65fb121724385832f556a13c35924cadf2ff1e28cc89050e00b2a3d43382093</citedby><cites>FETCH-LOGICAL-c506t-db65fb121724385832f556a13c35924cadf2ff1e28cc89050e00b2a3d43382093</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,3356,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23394043$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20978206$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MUMPRECHT, Viviane</creatorcontrib><creatorcontrib>HONER, Michael</creatorcontrib><creatorcontrib>VIGL, Benjamin</creatorcontrib><creatorcontrib>PROULX, Steven T</creatorcontrib><creatorcontrib>TRACHSEL, Eveline</creatorcontrib><creatorcontrib>KASPAR, Manuela</creatorcontrib><creatorcontrib>BANZIGER-TOBLER, Nadja E</creatorcontrib><creatorcontrib>SCHIBLI, Roger</creatorcontrib><creatorcontrib>NERI, Dario</creatorcontrib><creatorcontrib>DETMAR, Michael</creatorcontrib><title>In vivo Imaging of Inflammation- and Tumor-Induced Lymph Node Lymphangiogenesis by Immuno―Positron Emission Tomography</title><title>Cancer research (Chicago, Ill.)</title><addtitle>Cancer Res</addtitle><description>Metastasis to regional lymph nodes (LN) is a prognostic indicator for cancer progression. There is a great demand for sensitive and noninvasive methods to detect metastasis to LNs. Whereas conventional in vivo imaging approaches have focused on the detection of cancer cells, lymphangiogenesis within tumor-draining LNs might be the earliest sign of metastasis. In mouse models of LN lymphangiogenesis, we found that systemically injected antibodies to lymphatic epitopes accumulated in the lymphatic vasculature in tissues and LNs. Using a (124)I-labeled antibody against the lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1), we imaged, for the first time, inflammation- and tumor-draining LNs with expanded lymphatic networks in vivo by positron emission tomography (PET). Anti-LYVE-1 immuno-PET enabled visualization of lymphatic vessel expansion in LNs bearing metastases that were not detected by [(18)F]fluorodeoxyglucose-PET, which is clinically applied to detect cancer metastases. Immuno-PET with lymphatic-specific antibodies may open up new avenues for the early detection of metastasis, and the images obtained might be used as biomarkers for the progression of diseases associated with lymphangiogenesis.</description><subject>Animals</subject><subject>Antibodies, Monoclonal - immunology</subject><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Diagnostic Imaging</subject><subject>Female</subject><subject>Fluorodeoxyglucose F18</subject><subject>Glycoproteins - immunology</subject><subject>Humans</subject><subject>Inflammation - complications</subject><subject>Inflammation - immunology</subject><subject>Inflammation - pathology</subject><subject>Iodine Radioisotopes - pharmacokinetics</subject><subject>Luminescent Measurements</subject><subject>Lymph Nodes - diagnostic imaging</subject><subject>Lymph Nodes - immunology</subject><subject>Lymph Nodes - pathology</subject><subject>Lymphangiogenesis</subject><subject>Lymphatic Metastasis</subject><subject>Medical sciences</subject><subject>Melanoma, Experimental - complications</subject><subject>Melanoma, Experimental - immunology</subject><subject>Melanoma, Experimental - pathology</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Transgenic</subject><subject>Pharmacology. Drug treatments</subject><subject>Positron-Emission Tomography</subject><subject>Prognosis</subject><subject>Radiopharmaceuticals</subject><subject>Skin - metabolism</subject><subject>Tissue Distribution</subject><subject>Tumors</subject><subject>Vascular Endothelial Growth Factor C - metabolism</subject><subject>Vascular Endothelial Growth Factor Receptor-3 - immunology</subject><issn>0008-5472</issn><issn>1538-7445</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkctuGyEUhlHUqnGTPkIqNl2ScBnGzKZSZOUykpV04awRw8CYyoAFtlXv-hJ5wTxJGDl1kxW3__8O5z8AXBB8SQgXVxhjgXg1pZdaBUQwwqKpT8CEcCbQtKr4JzA5ak7B15x_lyMnmH8BpxQ3U0FxPQF_2gB3bhdh69XgwgCjhW2wK-W92rgYEFShh4utjwm1od9q08P53q-X8CH25rBVYXBxMMFkl2G3Lyi_DfHl7_OvmN0mxQBvvMu50OAi-jgktV7uz8Fnq1bZfHtbz8DT7c1ido_mj3ft7HqONMf1BvVdzW1HKJnSigkuGLWc14owzXhDK616S60lhgqtRYM5Nhh3VLG-Yqx02LAz8PPAXW87b3ptwiaplVwn51Xay6ic_PgS3FIOcScZawThtAD4AaBTzDkZe_QSLMdRyDFmOcYsZ9cP4-04iuL7_r7w0fUv-yL48SZQWauVTSpol__rygcqXNp4BcpylY4</recordid><startdate>20101101</startdate><enddate>20101101</enddate><creator>MUMPRECHT, Viviane</creator><creator>HONER, Michael</creator><creator>VIGL, Benjamin</creator><creator>PROULX, Steven T</creator><creator>TRACHSEL, Eveline</creator><creator>KASPAR, Manuela</creator><creator>BANZIGER-TOBLER, Nadja E</creator><creator>SCHIBLI, Roger</creator><creator>NERI, Dario</creator><creator>DETMAR, Michael</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20101101</creationdate><title>In vivo Imaging of Inflammation- and Tumor-Induced Lymph Node Lymphangiogenesis by Immuno―Positron Emission Tomography</title><author>MUMPRECHT, Viviane ; HONER, Michael ; VIGL, Benjamin ; PROULX, Steven T ; TRACHSEL, Eveline ; KASPAR, Manuela ; BANZIGER-TOBLER, Nadja E ; SCHIBLI, Roger ; NERI, Dario ; DETMAR, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c506t-db65fb121724385832f556a13c35924cadf2ff1e28cc89050e00b2a3d43382093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Antibodies, Monoclonal - immunology</topic><topic>Antineoplastic agents</topic><topic>Biological and medical sciences</topic><topic>Diagnostic Imaging</topic><topic>Female</topic><topic>Fluorodeoxyglucose F18</topic><topic>Glycoproteins - immunology</topic><topic>Humans</topic><topic>Inflammation - complications</topic><topic>Inflammation - immunology</topic><topic>Inflammation - pathology</topic><topic>Iodine Radioisotopes - pharmacokinetics</topic><topic>Luminescent Measurements</topic><topic>Lymph Nodes - diagnostic imaging</topic><topic>Lymph Nodes - immunology</topic><topic>Lymph Nodes - pathology</topic><topic>Lymphangiogenesis</topic><topic>Lymphatic Metastasis</topic><topic>Medical sciences</topic><topic>Melanoma, Experimental - complications</topic><topic>Melanoma, Experimental - immunology</topic><topic>Melanoma, Experimental - pathology</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Transgenic</topic><topic>Pharmacology. Drug treatments</topic><topic>Positron-Emission Tomography</topic><topic>Prognosis</topic><topic>Radiopharmaceuticals</topic><topic>Skin - metabolism</topic><topic>Tissue Distribution</topic><topic>Tumors</topic><topic>Vascular Endothelial Growth Factor C - metabolism</topic><topic>Vascular Endothelial Growth Factor Receptor-3 - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MUMPRECHT, Viviane</creatorcontrib><creatorcontrib>HONER, Michael</creatorcontrib><creatorcontrib>VIGL, Benjamin</creatorcontrib><creatorcontrib>PROULX, Steven T</creatorcontrib><creatorcontrib>TRACHSEL, Eveline</creatorcontrib><creatorcontrib>KASPAR, Manuela</creatorcontrib><creatorcontrib>BANZIGER-TOBLER, Nadja E</creatorcontrib><creatorcontrib>SCHIBLI, Roger</creatorcontrib><creatorcontrib>NERI, Dario</creatorcontrib><creatorcontrib>DETMAR, Michael</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer research (Chicago, Ill.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MUMPRECHT, Viviane</au><au>HONER, Michael</au><au>VIGL, Benjamin</au><au>PROULX, Steven T</au><au>TRACHSEL, Eveline</au><au>KASPAR, Manuela</au><au>BANZIGER-TOBLER, Nadja E</au><au>SCHIBLI, Roger</au><au>NERI, Dario</au><au>DETMAR, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vivo Imaging of Inflammation- and Tumor-Induced Lymph Node Lymphangiogenesis by Immuno―Positron Emission Tomography</atitle><jtitle>Cancer research (Chicago, Ill.)</jtitle><addtitle>Cancer Res</addtitle><date>2010-11-01</date><risdate>2010</risdate><volume>70</volume><issue>21</issue><spage>8842</spage><epage>8851</epage><pages>8842-8851</pages><issn>0008-5472</issn><eissn>1538-7445</eissn><coden>CNREA8</coden><abstract>Metastasis to regional lymph nodes (LN) is a prognostic indicator for cancer progression. There is a great demand for sensitive and noninvasive methods to detect metastasis to LNs. Whereas conventional in vivo imaging approaches have focused on the detection of cancer cells, lymphangiogenesis within tumor-draining LNs might be the earliest sign of metastasis. In mouse models of LN lymphangiogenesis, we found that systemically injected antibodies to lymphatic epitopes accumulated in the lymphatic vasculature in tissues and LNs. Using a (124)I-labeled antibody against the lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1), we imaged, for the first time, inflammation- and tumor-draining LNs with expanded lymphatic networks in vivo by positron emission tomography (PET). Anti-LYVE-1 immuno-PET enabled visualization of lymphatic vessel expansion in LNs bearing metastases that were not detected by [(18)F]fluorodeoxyglucose-PET, which is clinically applied to detect cancer metastases. Immuno-PET with lymphatic-specific antibodies may open up new avenues for the early detection of metastasis, and the images obtained might be used as biomarkers for the progression of diseases associated with lymphangiogenesis.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>20978206</pmid><doi>10.1158/0008-5472.can-10-0896</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Cancer research (Chicago, Ill.), 2010-11, Vol.70 (21), p.8842-8851 |
| issn | 0008-5472 1538-7445 |
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| source | MEDLINE; American Association for Cancer Research; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Antibodies, Monoclonal - immunology Antineoplastic agents Biological and medical sciences Diagnostic Imaging Female Fluorodeoxyglucose F18 Glycoproteins - immunology Humans Inflammation - complications Inflammation - immunology Inflammation - pathology Iodine Radioisotopes - pharmacokinetics Luminescent Measurements Lymph Nodes - diagnostic imaging Lymph Nodes - immunology Lymph Nodes - pathology Lymphangiogenesis Lymphatic Metastasis Medical sciences Melanoma, Experimental - complications Melanoma, Experimental - immunology Melanoma, Experimental - pathology Mice Mice, Inbred C57BL Mice, Transgenic Pharmacology. Drug treatments Positron-Emission Tomography Prognosis Radiopharmaceuticals Skin - metabolism Tissue Distribution Tumors Vascular Endothelial Growth Factor C - metabolism Vascular Endothelial Growth Factor Receptor-3 - immunology |
| title | In vivo Imaging of Inflammation- and Tumor-Induced Lymph Node Lymphangiogenesis by Immuno―Positron Emission Tomography |
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