Semireplication-competent vesicular stomatitis virus as a novel platform for oncolytic virotherapy

Among oncolytic viruses, the vesicular stomatitis virus (VSV) is especially potent and a highly promising agent for the treatment of cancer. But, even though effective against multiple tumor entities in preclinical animal models, replication-competent VSV exhibits inherent neurovirulence, which has...

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Veröffentlicht in:	Journal of molecular medicine (Berlin, Germany) Germany), 2012-08, Vol.90 (8), p.959-970
Hauptverfasser:	Muik, Alexander, Dold, Catherine, Geiß, Yvonne, Volk, Andreas, Werbizki, Marina, Dietrich, Ursula, von Laer, Dorothee
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Antitumor activity Biological and medical sciences Biomedical and Life Sciences Biomedicine Brain Cancer Catalytic subunits Cell Line, Tumor Cells, Cultured Coding Cricetinae Deletion mutant Development Expression vectors Gene therapy Gene transfer General aspects Glioblastoma - metabolism Glioblastoma - therapy glioblastoma cells Human Genetics Humans Interferon-alpha - metabolism Internal Medicine Medical sciences Mice Mice, SCID Molecular Medicine Neurological diseases Neurology Neurotoxicity Neurovirulence Oncolysis Oncolytic Virotherapy - methods Original Original Article Phosphoproteins Reversion Side effects spheroids Transgenes Tumors Tumors of the nervous system. Phacomatoses Vaccines Vesicular stomatitis Indiana virus - genetics Vesicular stomatitis Indiana virus - physiology Vesicular stomatitis virus Xenografts
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