Green tea consumption, inflammation and the risk of primary hepatocellular carcinoma in a Chinese population
Abstract Objective : Green tea has been found to possess anti-inflammatory, anti-oxidative and anti-carcinogenic properties. The present study examines the association between green tea drinking and hepatocellular carcinoma (HCC) and its interactions with other risk or protective factors and single...
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| Veröffentlicht in: | Cancer epidemiology 2011-08, Vol.35 (4), p.362-368 |
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| creator | Li, Yanli Chang, Shen-Chih Goldstein, Binh Y Scheider, William L Cai, Lin You, Nai-Chieh Y Tarleton, Heather P Ding, Baoguo Zhao, Jinkou Wu, Ming Jiang, Qingwu Yu, Shunzhang Rao, Jianyu Lu, Qing-Yi Zhang, Zuo-Feng Mu, Lina |
| description | Abstract Objective : Green tea has been found to possess anti-inflammatory, anti-oxidative and anti-carcinogenic properties. The present study examines the association between green tea drinking and hepatocellular carcinoma (HCC) and its interactions with other risk or protective factors and single nucleotide polymorphisms (SNP) of inflammation and oxidative stress related genes. Methods : A population-based case-control study with 204 primary HCC cases and 415 healthy controls was conducted in Taixing, China. Epidemiological data were collected using a standard questionnaire. SNPs of genes of the inflammation and metabolic pathways were genotyped at the UCLA Molecular Epidemiology Laboratory. Logistic regression was performed to estimate adjusted odds ratios and 95% confidence intervals. Results : Longer duration and larger quantities of green tea consumption were inversely associated with primary HCC. Individuals who drank green tea longer than 30 years were at lowest risk (adjusted OR = 0.44, 95% CI: 0.19–0.96) compared with non-drinkers. A strong interaction was observed between green tea drinking and alcohol consumption (adjusted OR for interaction = 3.40, 95% CI: 1.26–9.16). Green tea drinking was also observed to have a potential effect modification on HBV/HCV infection, smoking and polymorphisms of inflammation related cytokines, especially for IL-10. Conclusion : Green tea consumption may protect against development of primary HCC. Potential effect modifications of green tea on associations between primary HCC and alcohol drinking, HBV/HCV infection, and inflammation-related SNPs were suggested. |
| doi_str_mv | 10.1016/j.canep.2011.01.005 |
| format | Article |
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The present study examines the association between green tea drinking and hepatocellular carcinoma (HCC) and its interactions with other risk or protective factors and single nucleotide polymorphisms (SNP) of inflammation and oxidative stress related genes. Methods : A population-based case-control study with 204 primary HCC cases and 415 healthy controls was conducted in Taixing, China. Epidemiological data were collected using a standard questionnaire. SNPs of genes of the inflammation and metabolic pathways were genotyped at the UCLA Molecular Epidemiology Laboratory. Logistic regression was performed to estimate adjusted odds ratios and 95% confidence intervals. Results : Longer duration and larger quantities of green tea consumption were inversely associated with primary HCC. Individuals who drank green tea longer than 30 years were at lowest risk (adjusted OR = 0.44, 95% CI: 0.19–0.96) compared with non-drinkers. A strong interaction was observed between green tea drinking and alcohol consumption (adjusted OR for interaction = 3.40, 95% CI: 1.26–9.16). Green tea drinking was also observed to have a potential effect modification on HBV/HCV infection, smoking and polymorphisms of inflammation related cytokines, especially for IL-10. Conclusion : Green tea consumption may protect against development of primary HCC. Potential effect modifications of green tea on associations between primary HCC and alcohol drinking, HBV/HCV infection, and inflammation-related SNPs were suggested.</description><identifier>ISSN: 1877-7821</identifier><identifier>EISSN: 1877-783X</identifier><identifier>DOI: 10.1016/j.canep.2011.01.005</identifier><identifier>PMID: 21315679</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Adult ; Aged ; Alcohol ; Bias ; Cancer ; Carcinoma, Hepatocellular - epidemiology ; Carcinoma, Hepatocellular - genetics ; Case-Control Studies ; China - epidemiology ; Consumption ; Cytokines ; Epidemiology ; Fatalities ; Female ; Gender ; Gene expression ; Green tea ; Health sciences ; Hematology, Oncology and Palliative Medicine ; Hepatitis B virus ; Hepatitis C virus ; Humans ; Inflammation ; Inflammation - epidemiology ; Inflammation - genetics ; Internal Medicine ; Liver cancer ; Liver Neoplasms - epidemiology ; Liver Neoplasms - genetics ; Male ; Middle Aged ; Multivariate analysis ; Polymorphism, Single Nucleotide ; Polyphenols ; Primary hepatocellular carcinoma ; Risk Factors ; Tea ; Young Adult</subject><ispartof>Cancer epidemiology, 2011-08, Vol.35 (4), p.362-368</ispartof><rights>Elsevier Ltd</rights><rights>2011 Elsevier Ltd</rights><rights>Copyright © 2011 Elsevier Ltd. All rights reserved.</rights><rights>2011 Elsevier Ltd. All rights reserved. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c639t-4446ef434648967c8fda35be719de367e79a8fafb96873b9f516018cf53dadf53</citedby><cites>FETCH-LOGICAL-c639t-4446ef434648967c8fda35be719de367e79a8fafb96873b9f516018cf53dadf53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1032598654?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21315679$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Yanli</creatorcontrib><creatorcontrib>Chang, Shen-Chih</creatorcontrib><creatorcontrib>Goldstein, Binh Y</creatorcontrib><creatorcontrib>Scheider, William L</creatorcontrib><creatorcontrib>Cai, Lin</creatorcontrib><creatorcontrib>You, Nai-Chieh Y</creatorcontrib><creatorcontrib>Tarleton, Heather P</creatorcontrib><creatorcontrib>Ding, Baoguo</creatorcontrib><creatorcontrib>Zhao, Jinkou</creatorcontrib><creatorcontrib>Wu, Ming</creatorcontrib><creatorcontrib>Jiang, Qingwu</creatorcontrib><creatorcontrib>Yu, Shunzhang</creatorcontrib><creatorcontrib>Rao, Jianyu</creatorcontrib><creatorcontrib>Lu, Qing-Yi</creatorcontrib><creatorcontrib>Zhang, Zuo-Feng</creatorcontrib><creatorcontrib>Mu, Lina</creatorcontrib><title>Green tea consumption, inflammation and the risk of primary hepatocellular carcinoma in a Chinese population</title><title>Cancer epidemiology</title><addtitle>Cancer Epidemiol</addtitle><description>Abstract Objective : Green tea has been found to possess anti-inflammatory, anti-oxidative and anti-carcinogenic properties. The present study examines the association between green tea drinking and hepatocellular carcinoma (HCC) and its interactions with other risk or protective factors and single nucleotide polymorphisms (SNP) of inflammation and oxidative stress related genes. Methods : A population-based case-control study with 204 primary HCC cases and 415 healthy controls was conducted in Taixing, China. Epidemiological data were collected using a standard questionnaire. SNPs of genes of the inflammation and metabolic pathways were genotyped at the UCLA Molecular Epidemiology Laboratory. Logistic regression was performed to estimate adjusted odds ratios and 95% confidence intervals. Results : Longer duration and larger quantities of green tea consumption were inversely associated with primary HCC. Individuals who drank green tea longer than 30 years were at lowest risk (adjusted OR = 0.44, 95% CI: 0.19–0.96) compared with non-drinkers. A strong interaction was observed between green tea drinking and alcohol consumption (adjusted OR for interaction = 3.40, 95% CI: 1.26–9.16). Green tea drinking was also observed to have a potential effect modification on HBV/HCV infection, smoking and polymorphisms of inflammation related cytokines, especially for IL-10. Conclusion : Green tea consumption may protect against development of primary HCC. Potential effect modifications of green tea on associations between primary HCC and alcohol drinking, HBV/HCV infection, and inflammation-related SNPs were suggested.</description><subject>Adult</subject><subject>Aged</subject><subject>Alcohol</subject><subject>Bias</subject><subject>Cancer</subject><subject>Carcinoma, Hepatocellular - epidemiology</subject><subject>Carcinoma, Hepatocellular - genetics</subject><subject>Case-Control Studies</subject><subject>China - epidemiology</subject><subject>Consumption</subject><subject>Cytokines</subject><subject>Epidemiology</subject><subject>Fatalities</subject><subject>Female</subject><subject>Gender</subject><subject>Gene expression</subject><subject>Green tea</subject><subject>Health sciences</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Hepatitis B virus</subject><subject>Hepatitis C virus</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammation - epidemiology</subject><subject>Inflammation - genetics</subject><subject>Internal Medicine</subject><subject>Liver cancer</subject><subject>Liver Neoplasms - epidemiology</subject><subject>Liver Neoplasms - genetics</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate analysis</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Polyphenols</subject><subject>Primary hepatocellular carcinoma</subject><subject>Risk Factors</subject><subject>Tea</subject><subject>Young Adult</subject><issn>1877-7821</issn><issn>1877-783X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFUt9rFDEQXsRia_UvECTggy_emWw2vx4slMPWQsEHFXwLuezEy3U3WZPdQv97s73zWvtiGPKD-ebLfDNTVW8IXhJM-Mft0poAw7LGhCxxMcyeVSdECrEQkv58frjX5Lh6mfMWY84JYS-q45pQwrhQJ1V3mQACGsEgG0Oe-mH0MXxAPrjO9L2ZX8iEFo0bQMnnGxQdGpLvTbpDGxjMGC103dSZhKxJ1ofYmxKNDFptfIAMaIhDcc9Er6ojZ7oMr_fnafXj4vP31ZfF9dfLq9X59cJyqsZF0zQcXEMb3kjFhZWuNZStQRDVAuUChDLSGbdWXAq6Vo4Rjom0jtHWtGU_rc52vMO07qG1EMZkOr1PW0fj9b-e4Df6V7zVlKpSIVUI3u8JUvw9QR517_OssxQ8TllLyTATmOOCfPcEuY1TCkWdJpjWTEnOmoKiO5RNMecE7pALwXpupt7q-2bquZkaF8OzjLePZRxi_navAD7tAFCKeesh6Ww9BAutT2BH3Ub_nw_OnsTbzgdvTXcDd5AflOhca6y_zfM0jxMhuCxO6R9dT8hX</recordid><startdate>20110801</startdate><enddate>20110801</enddate><creator>Li, 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inflammation and the risk of primary hepatocellular carcinoma in a Chinese population</title><author>Li, Yanli ; Chang, Shen-Chih ; Goldstein, Binh Y ; Scheider, William L ; Cai, Lin ; You, Nai-Chieh Y ; Tarleton, Heather P ; Ding, Baoguo ; Zhao, Jinkou ; Wu, Ming ; Jiang, Qingwu ; Yu, Shunzhang ; Rao, Jianyu ; Lu, Qing-Yi ; Zhang, Zuo-Feng ; Mu, Lina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c639t-4446ef434648967c8fda35be719de367e79a8fafb96873b9f516018cf53dadf53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Alcohol</topic><topic>Bias</topic><topic>Cancer</topic><topic>Carcinoma, Hepatocellular - epidemiology</topic><topic>Carcinoma, Hepatocellular - genetics</topic><topic>Case-Control Studies</topic><topic>China - epidemiology</topic><topic>Consumption</topic><topic>Cytokines</topic><topic>Epidemiology</topic><topic>Fatalities</topic><topic>Female</topic><topic>Gender</topic><topic>Gene expression</topic><topic>Green tea</topic><topic>Health sciences</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Hepatitis B virus</topic><topic>Hepatitis C virus</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Inflammation - epidemiology</topic><topic>Inflammation - genetics</topic><topic>Internal Medicine</topic><topic>Liver cancer</topic><topic>Liver Neoplasms - epidemiology</topic><topic>Liver Neoplasms - genetics</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate analysis</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Polyphenols</topic><topic>Primary hepatocellular carcinoma</topic><topic>Risk Factors</topic><topic>Tea</topic><topic>Young 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Lina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Green tea consumption, inflammation and the risk of primary hepatocellular carcinoma in a Chinese population</atitle><jtitle>Cancer epidemiology</jtitle><addtitle>Cancer Epidemiol</addtitle><date>2011-08-01</date><risdate>2011</risdate><volume>35</volume><issue>4</issue><spage>362</spage><epage>368</epage><pages>362-368</pages><issn>1877-7821</issn><eissn>1877-783X</eissn><abstract>Abstract Objective : Green tea has been found to possess anti-inflammatory, anti-oxidative and anti-carcinogenic properties. The present study examines the association between green tea drinking and hepatocellular carcinoma (HCC) and its interactions with other risk or protective factors and single nucleotide polymorphisms (SNP) of inflammation and oxidative stress related genes. Methods : A population-based case-control study with 204 primary HCC cases and 415 healthy controls was conducted in Taixing, China. Epidemiological data were collected using a standard questionnaire. SNPs of genes of the inflammation and metabolic pathways were genotyped at the UCLA Molecular Epidemiology Laboratory. Logistic regression was performed to estimate adjusted odds ratios and 95% confidence intervals. Results : Longer duration and larger quantities of green tea consumption were inversely associated with primary HCC. Individuals who drank green tea longer than 30 years were at lowest risk (adjusted OR = 0.44, 95% CI: 0.19–0.96) compared with non-drinkers. A strong interaction was observed between green tea drinking and alcohol consumption (adjusted OR for interaction = 3.40, 95% CI: 1.26–9.16). Green tea drinking was also observed to have a potential effect modification on HBV/HCV infection, smoking and polymorphisms of inflammation related cytokines, especially for IL-10. Conclusion : Green tea consumption may protect against development of primary HCC. Potential effect modifications of green tea on associations between primary HCC and alcohol drinking, HBV/HCV infection, and inflammation-related SNPs were suggested.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>21315679</pmid><doi>10.1016/j.canep.2011.01.005</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Cancer epidemiology, 2011-08, Vol.35 (4), p.362-368 |
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| subjects | Adult Aged Alcohol Bias Cancer Carcinoma, Hepatocellular - epidemiology Carcinoma, Hepatocellular - genetics Case-Control Studies China - epidemiology Consumption Cytokines Epidemiology Fatalities Female Gender Gene expression Green tea Health sciences Hematology, Oncology and Palliative Medicine Hepatitis B virus Hepatitis C virus Humans Inflammation Inflammation - epidemiology Inflammation - genetics Internal Medicine Liver cancer Liver Neoplasms - epidemiology Liver Neoplasms - genetics Male Middle Aged Multivariate analysis Polymorphism, Single Nucleotide Polyphenols Primary hepatocellular carcinoma Risk Factors Tea Young Adult |
| title | Green tea consumption, inflammation and the risk of primary hepatocellular carcinoma in a Chinese population |
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