Evolution of the casein multigene family: conserved sequences in the 5′ flanking and exon regions
The rat α- and bovine αs1-casein genes have been isolated and their 5′ sequences determined. The rat α-, β-, γ- and bovine αs1-casein genes contain similar 5′ exon arrangements in which the 5′ noncoding, signal peptide and casein klnase phosphorylatlon sequences are each encoded by separate exons. T...
Gespeichert in:
| Veröffentlicht in: | Nucleic acids research 1986-02, Vol.14 (4), p.1883-1902 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1902 |
|---|---|
| container_issue | 4 |
| container_start_page | 1883 |
| container_title | Nucleic acids research |
| container_volume | 14 |
| creator | Yu-Lee, Li-yuan Richter-Mann, Lizabeth Couch, Craig H. Stewart, A.Francis Mackinlay, Anthony G. Rosen, Jeffrey M. |
| description | The rat α- and bovine αs1-casein genes have been isolated and their 5′ sequences determined. The rat α-, β-, γ- and bovine αs1-casein genes contain similar 5′ exon arrangements in which the 5′ noncoding, signal peptide and casein klnase phosphorylatlon sequences are each encoded by separate exons. These findings support the hypothesis that during evolution, the family of casein genes arose by a process involving exon recruitment followed by intra-genic and intergenic duplication of a primordial gene. Several highly conserved regions in the first 200 base pairs of the 5′ flanking DNA have been identified. Additional sequence homology extending up to 550 base pairs upstream of the CAP site has been found between the rat α- and bovine αs1-casein sequences. Unexpectedly, the 5′ flanking promoter regions are conserved to a greater extent than both the entire mature coding and intron regions of these genes. These conserved 5′ flanking sequences may contain potential cis regulatory elements which are responsible for the coordinate expression of the functionally-related casein genes during mammary gland development. |
| doi_str_mv | 10.1093/nar/14.4.1883 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_339580</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>19362726</sourcerecordid><originalsourceid>FETCH-LOGICAL-c576t-2da0ab0a4a57ebd287b8f028f46ba0b552ebabbf5e09a77897b2dd91558d86ec3</originalsourceid><addsrcrecordid>eNqNkc9rFDEcxYModa0ePQo5iLfZ5ncyggcp1QoVEZQWLyHJfGcbO5upyczS3vyb_JP8S8zSZdWTnnJ4n_eSl4fQU0qWlLT8KLl8RMVSLKkx_B5aUK5YI1rF7qMF4UQ2lAjzED0q5SshVFApDtABbyUjhCxQONmMwzzFMeGxx9Ml4OAKxITX8zDFFSTAvVvH4fYlDmMqkDfQ4QLfZkgBCq7g1iN_fv-B-8Glq5hW2KUOw01NzLCqweUxetC7ocCT3XmIPr85-XR82px9ePvu-PVZE6RWU8M6R5wnTjipwXfMaG96wkwvlHfES8nAO-97CaR1WptWe9Z1LZXSdEZB4Ifo1V3u9ezX0AVIU3aDvc5x7fKtHV20fyspXtrVuLG8foch1f9i589jLVgmu44lwFB7wTgXq5Xmhkv1T5C2dQPN_gMUhijJZAWbOzDksZQM_f7VlNjtzLbOXHEr7Hbmyj_7s-qe3u1a9ec73ZXghj67FGLZY7pVxGjx-9pYJrjZyy5f2dpVS3t68cUSdU7Nxftz-5H_AoImwr4</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>14806525</pqid></control><display><type>article</type><title>Evolution of the casein multigene family: conserved sequences in the 5′ flanking and exon regions</title><source>Oxford University Press Journals Digital Archive legacy</source><source>MEDLINE</source><source>PubMed Central</source><creator>Yu-Lee, Li-yuan ; Richter-Mann, Lizabeth ; Couch, Craig H. ; Stewart, A.Francis ; Mackinlay, Anthony G. ; Rosen, Jeffrey M.</creator><creatorcontrib>Yu-Lee, Li-yuan ; Richter-Mann, Lizabeth ; Couch, Craig H. ; Stewart, A.Francis ; Mackinlay, Anthony G. ; Rosen, Jeffrey M.</creatorcontrib><description>The rat α- and bovine αs1-casein genes have been isolated and their 5′ sequences determined. The rat α-, β-, γ- and bovine αs1-casein genes contain similar 5′ exon arrangements in which the 5′ noncoding, signal peptide and casein klnase phosphorylatlon sequences are each encoded by separate exons. These findings support the hypothesis that during evolution, the family of casein genes arose by a process involving exon recruitment followed by intra-genic and intergenic duplication of a primordial gene. Several highly conserved regions in the first 200 base pairs of the 5′ flanking DNA have been identified. Additional sequence homology extending up to 550 base pairs upstream of the CAP site has been found between the rat α- and bovine αs1-casein sequences. Unexpectedly, the 5′ flanking promoter regions are conserved to a greater extent than both the entire mature coding and intron regions of these genes. These conserved 5′ flanking sequences may contain potential cis regulatory elements which are responsible for the coordinate expression of the functionally-related casein genes during mammary gland development.</description><identifier>ISSN: 0305-1048</identifier><identifier>EISSN: 1362-4962</identifier><identifier>DOI: 10.1093/nar/14.4.1883</identifier><identifier>PMID: 3952000</identifier><identifier>CODEN: NARHAD</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Animals ; Base Sequence ; Biological and medical sciences ; Biological Evolution ; Caseins - genetics ; Cattle ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation ; Genes ; Genetic Linkage ; Genetics of eukaryotes. Biological and molecular evolution ; Promoter Regions, Genetic ; Protein Sorting Signals - genetics ; Rats ; Sequence Homology, Nucleic Acid ; Space life sciences</subject><ispartof>Nucleic acids research, 1986-02, Vol.14 (4), p.1883-1902</ispartof><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c576t-2da0ab0a4a57ebd287b8f028f46ba0b552ebabbf5e09a77897b2dd91558d86ec3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC339580/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC339580/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7960874$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3952000$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yu-Lee, Li-yuan</creatorcontrib><creatorcontrib>Richter-Mann, Lizabeth</creatorcontrib><creatorcontrib>Couch, Craig H.</creatorcontrib><creatorcontrib>Stewart, A.Francis</creatorcontrib><creatorcontrib>Mackinlay, Anthony G.</creatorcontrib><creatorcontrib>Rosen, Jeffrey M.</creatorcontrib><title>Evolution of the casein multigene family: conserved sequences in the 5′ flanking and exon regions</title><title>Nucleic acids research</title><addtitle>Nucleic Acids Res</addtitle><description>The rat α- and bovine αs1-casein genes have been isolated and their 5′ sequences determined. The rat α-, β-, γ- and bovine αs1-casein genes contain similar 5′ exon arrangements in which the 5′ noncoding, signal peptide and casein klnase phosphorylatlon sequences are each encoded by separate exons. These findings support the hypothesis that during evolution, the family of casein genes arose by a process involving exon recruitment followed by intra-genic and intergenic duplication of a primordial gene. Several highly conserved regions in the first 200 base pairs of the 5′ flanking DNA have been identified. Additional sequence homology extending up to 550 base pairs upstream of the CAP site has been found between the rat α- and bovine αs1-casein sequences. Unexpectedly, the 5′ flanking promoter regions are conserved to a greater extent than both the entire mature coding and intron regions of these genes. These conserved 5′ flanking sequences may contain potential cis regulatory elements which are responsible for the coordinate expression of the functionally-related casein genes during mammary gland development.</description><subject>Animals</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Biological Evolution</subject><subject>Caseins - genetics</subject><subject>Cattle</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation</subject><subject>Genes</subject><subject>Genetic Linkage</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Promoter Regions, Genetic</subject><subject>Protein Sorting Signals - genetics</subject><subject>Rats</subject><subject>Sequence Homology, Nucleic Acid</subject><subject>Space life sciences</subject><issn>0305-1048</issn><issn>1362-4962</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc9rFDEcxYModa0ePQo5iLfZ5ncyggcp1QoVEZQWLyHJfGcbO5upyczS3vyb_JP8S8zSZdWTnnJ4n_eSl4fQU0qWlLT8KLl8RMVSLKkx_B5aUK5YI1rF7qMF4UQ2lAjzED0q5SshVFApDtABbyUjhCxQONmMwzzFMeGxx9Ml4OAKxITX8zDFFSTAvVvH4fYlDmMqkDfQ4QLfZkgBCq7g1iN_fv-B-8Glq5hW2KUOw01NzLCqweUxetC7ocCT3XmIPr85-XR82px9ePvu-PVZE6RWU8M6R5wnTjipwXfMaG96wkwvlHfES8nAO-97CaR1WptWe9Z1LZXSdEZB4Ifo1V3u9ezX0AVIU3aDvc5x7fKtHV20fyspXtrVuLG8foch1f9i589jLVgmu44lwFB7wTgXq5Xmhkv1T5C2dQPN_gMUhijJZAWbOzDksZQM_f7VlNjtzLbOXHEr7Hbmyj_7s-qe3u1a9ec73ZXghj67FGLZY7pVxGjx-9pYJrjZyy5f2dpVS3t68cUSdU7Nxftz-5H_AoImwr4</recordid><startdate>19860225</startdate><enddate>19860225</enddate><creator>Yu-Lee, Li-yuan</creator><creator>Richter-Mann, Lizabeth</creator><creator>Couch, Craig H.</creator><creator>Stewart, A.Francis</creator><creator>Mackinlay, Anthony G.</creator><creator>Rosen, Jeffrey M.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19860225</creationdate><title>Evolution of the casein multigene family: conserved sequences in the 5′ flanking and exon regions</title><author>Yu-Lee, Li-yuan ; Richter-Mann, Lizabeth ; Couch, Craig H. ; Stewart, A.Francis ; Mackinlay, Anthony G. ; Rosen, Jeffrey M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c576t-2da0ab0a4a57ebd287b8f028f46ba0b552ebabbf5e09a77897b2dd91558d86ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Animals</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Biological Evolution</topic><topic>Caseins - genetics</topic><topic>Cattle</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression Regulation</topic><topic>Genes</topic><topic>Genetic Linkage</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Promoter Regions, Genetic</topic><topic>Protein Sorting Signals - genetics</topic><topic>Rats</topic><topic>Sequence Homology, Nucleic Acid</topic><topic>Space life sciences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yu-Lee, Li-yuan</creatorcontrib><creatorcontrib>Richter-Mann, Lizabeth</creatorcontrib><creatorcontrib>Couch, Craig H.</creatorcontrib><creatorcontrib>Stewart, A.Francis</creatorcontrib><creatorcontrib>Mackinlay, Anthony G.</creatorcontrib><creatorcontrib>Rosen, Jeffrey M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nucleic acids research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yu-Lee, Li-yuan</au><au>Richter-Mann, Lizabeth</au><au>Couch, Craig H.</au><au>Stewart, A.Francis</au><au>Mackinlay, Anthony G.</au><au>Rosen, Jeffrey M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evolution of the casein multigene family: conserved sequences in the 5′ flanking and exon regions</atitle><jtitle>Nucleic acids research</jtitle><addtitle>Nucleic Acids Res</addtitle><date>1986-02-25</date><risdate>1986</risdate><volume>14</volume><issue>4</issue><spage>1883</spage><epage>1902</epage><pages>1883-1902</pages><issn>0305-1048</issn><eissn>1362-4962</eissn><coden>NARHAD</coden><abstract>The rat α- and bovine αs1-casein genes have been isolated and their 5′ sequences determined. The rat α-, β-, γ- and bovine αs1-casein genes contain similar 5′ exon arrangements in which the 5′ noncoding, signal peptide and casein klnase phosphorylatlon sequences are each encoded by separate exons. These findings support the hypothesis that during evolution, the family of casein genes arose by a process involving exon recruitment followed by intra-genic and intergenic duplication of a primordial gene. Several highly conserved regions in the first 200 base pairs of the 5′ flanking DNA have been identified. Additional sequence homology extending up to 550 base pairs upstream of the CAP site has been found between the rat α- and bovine αs1-casein sequences. Unexpectedly, the 5′ flanking promoter regions are conserved to a greater extent than both the entire mature coding and intron regions of these genes. These conserved 5′ flanking sequences may contain potential cis regulatory elements which are responsible for the coordinate expression of the functionally-related casein genes during mammary gland development.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>3952000</pmid><doi>10.1093/nar/14.4.1883</doi><tpages>20</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0305-1048 |
| ispartof | Nucleic acids research, 1986-02, Vol.14 (4), p.1883-1902 |
| issn | 0305-1048 1362-4962 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_339580 |
| source | Oxford University Press Journals Digital Archive legacy; MEDLINE; PubMed Central |
| subjects | Animals Base Sequence Biological and medical sciences Biological Evolution Caseins - genetics Cattle Fundamental and applied biological sciences. Psychology Gene Expression Regulation Genes Genetic Linkage Genetics of eukaryotes. Biological and molecular evolution Promoter Regions, Genetic Protein Sorting Signals - genetics Rats Sequence Homology, Nucleic Acid Space life sciences |
| title | Evolution of the casein multigene family: conserved sequences in the 5′ flanking and exon regions |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T15%3A52%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Evolution%20of%20the%20casein%20multigene%20family:%20conserved%20sequences%20in%20the%205%E2%80%B2%20flanking%20and%20exon%20regions&rft.jtitle=Nucleic%20acids%20research&rft.au=Yu-Lee,%20Li-yuan&rft.date=1986-02-25&rft.volume=14&rft.issue=4&rft.spage=1883&rft.epage=1902&rft.pages=1883-1902&rft.issn=0305-1048&rft.eissn=1362-4962&rft.coden=NARHAD&rft_id=info:doi/10.1093/nar/14.4.1883&rft_dat=%3Cproquest_pubme%3E19362726%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=14806525&rft_id=info:pmid/3952000&rfr_iscdi=true |