Are Free Radicals Involved in IspH Catalysis? An EPR and Crystallographic Investigation

The [4Fe–4S] protein IspH in the methylerythritol phosphate isoprenoid biosynthesis pathway is an important anti-infective drug target, but its mechanism of action is still the subject of debate. Here, by using electron paramagnetic resonance (EPR) spectroscopy and 2H, 17O, and 57Fe isotopic labelin...

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Veröffentlicht in:	Journal of the American Chemical Society 2012-07, Vol.134 (27), p.11225-11234
Hauptverfasser:	Wang, Weixue, Wang, Ke, Span, Ingrid, Jauch, Johann, Bacher, Adelbert, Groll, Michael, Oldfield, Eric
Format:	Artikel
Sprache:	eng
Schlagworte:	Crystallography, X-Ray Electron Spin Resonance Spectroscopy Escherichia coli - chemistry Escherichia coli - genetics Escherichia coli - metabolism Escherichia coli Proteins - chemistry Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Free Radicals - metabolism Models, Molecular Mutation Oxidoreductases - chemistry Oxidoreductases - genetics Oxidoreductases - metabolism
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