Effect of quaternary ammonium and silver nanoparticle-containing adhesives on dentin bond strength and dental plaque microcosm biofilms
Abstract Objective Antibacterial bonding agents are promising to hinder the residual and invading bacteria at the tooth–restoration interfaces. The objectives of this study were to develop an antibacterial bonding agent by incorporation of quaternary ammonium dimethacrylate (QADM) and nanoparticles...
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| Veröffentlicht in: | Dental materials 2012-08, Vol.28 (8), p.842-852 |
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| creator | Zhang, Ke Melo, Mary Anne S Cheng, Lei Weir, Michael D Bai, Yuxing Xu, Hockin H.K |
| description | Abstract Objective Antibacterial bonding agents are promising to hinder the residual and invading bacteria at the tooth–restoration interfaces. The objectives of this study were to develop an antibacterial bonding agent by incorporation of quaternary ammonium dimethacrylate (QADM) and nanoparticles of silver (NAg), and to investigate the effect of QADM-NAg adhesive and primer on dentin bond strength and plaque microcosm biofilm response for the first time. Methods Scotchbond Multi-Purpose adhesive and primer were used as control. Experimental adhesive and primer were made by adding QADM and NAg into control adhesive and primer. Human dentin shear bond strengths were measured ( n = 10). A dental plaque microcosm biofilm model with human saliva as inoculum was used to investigate biofilm metabolic activity, colony-forming unit (CFU) counts, lactic acid production, and live/dead staining assay ( n = 6). Results Adding QADM and NAg into adhesive and primer did not compromise the dentin shear bond strength which ranged from 30 to 35 MPa ( p > 0.1). Scanning electron microscopy (SEM) examinations revealed numerous resin tags, which were similar for the control and the QADM and NAg groups. Adding QADM or NAg markedly reduced the biofilm viability, compared to adhesive control. QADM and NAg together in the adhesive had a much stronger antibacterial effect than using each agent alone ( p < 0.05). Adding QADM and NAg in both adhesive and primer had the strongest antibacterial activity, reducing metabolic activity, CFU, and lactic acid by an order of magnitude, compared to control. Significance Without compromising dentin bond strength and resin tag formation, the QADM and NAg containing adhesive and primer achieved strong antibacterial effects against microcosm biofilms for the first time. QADM-NAg adhesive and primer are promising to combat residual bacteria in tooth cavity and invading bacteria at the margins, thereby to inhibit secondary caries. QADM and NAg incorporation may have a wide applicability to other dental bonding systems. |
| doi_str_mv | 10.1016/j.dental.2012.04.027 |
| format | Article |
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The objectives of this study were to develop an antibacterial bonding agent by incorporation of quaternary ammonium dimethacrylate (QADM) and nanoparticles of silver (NAg), and to investigate the effect of QADM-NAg adhesive and primer on dentin bond strength and plaque microcosm biofilm response for the first time. Methods Scotchbond Multi-Purpose adhesive and primer were used as control. Experimental adhesive and primer were made by adding QADM and NAg into control adhesive and primer. Human dentin shear bond strengths were measured ( n = 10). A dental plaque microcosm biofilm model with human saliva as inoculum was used to investigate biofilm metabolic activity, colony-forming unit (CFU) counts, lactic acid production, and live/dead staining assay ( n = 6). Results Adding QADM and NAg into adhesive and primer did not compromise the dentin shear bond strength which ranged from 30 to 35 MPa ( p > 0.1). Scanning electron microscopy (SEM) examinations revealed numerous resin tags, which were similar for the control and the QADM and NAg groups. Adding QADM or NAg markedly reduced the biofilm viability, compared to adhesive control. QADM and NAg together in the adhesive had a much stronger antibacterial effect than using each agent alone ( p < 0.05). Adding QADM and NAg in both adhesive and primer had the strongest antibacterial activity, reducing metabolic activity, CFU, and lactic acid by an order of magnitude, compared to control. Significance Without compromising dentin bond strength and resin tag formation, the QADM and NAg containing adhesive and primer achieved strong antibacterial effects against microcosm biofilms for the first time. QADM-NAg adhesive and primer are promising to combat residual bacteria in tooth cavity and invading bacteria at the margins, thereby to inhibit secondary caries. QADM and NAg incorporation may have a wide applicability to other dental bonding systems.</description><identifier>ISSN: 0109-5641</identifier><identifier>EISSN: 1879-0097</identifier><identifier>DOI: 10.1016/j.dental.2012.04.027</identifier><identifier>PMID: 22592165</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adhesives ; Adult ; Advanced Basic Science ; Analysis of Variance ; Anti-Bacterial Agents - pharmacology ; Antibacterial dental adhesive ; Antiinfectives and antibacterials ; Bacteria ; Biofilms ; Biofilms - drug effects ; Bonding strength ; Caries inhibition ; Colony Count, Microbial ; Dental Bonding ; Dental Leakage - prevention & control ; Dental materials ; Dental Plaque - metabolism ; Dental Stress Analysis ; Dentin ; Dentin bond strength ; Dentin-Bonding Agents - chemistry ; Dentin-Bonding Agents - pharmacology ; Dentistry ; Human saliva microcosm biofilm ; Humans ; Lactic Acid - metabolism ; Materials Testing ; Microbial Viability - drug effects ; Molar ; Nanoparticles ; Nanostructure ; Quaternary Ammonium Compounds - chemistry ; Quaternary Ammonium Compounds - pharmacology ; Quaternary ammonium dimethacrylate ; Resin Cements - chemistry ; Resin Cements - pharmacology ; Saliva - microbiology ; Shear Strength ; Silver Compounds - chemistry ; Silver Compounds - pharmacology ; Silver nanoparticles</subject><ispartof>Dental materials, 2012-08, Vol.28 (8), p.842-852</ispartof><rights>Academy of Dental Materials</rights><rights>2012 Academy of Dental Materials</rights><rights>Copyright © 2012 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.</rights><rights>2004 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved. 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c617t-6b748cabbbcffb47951ff6d41fb1e5d45a9de97ff1bfa98ee7c782b5fd6356573</citedby><cites>FETCH-LOGICAL-c617t-6b748cabbbcffb47951ff6d41fb1e5d45a9de97ff1bfa98ee7c782b5fd6356573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0109564112001339$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22592165$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Ke</creatorcontrib><creatorcontrib>Melo, Mary Anne S</creatorcontrib><creatorcontrib>Cheng, Lei</creatorcontrib><creatorcontrib>Weir, Michael D</creatorcontrib><creatorcontrib>Bai, Yuxing</creatorcontrib><creatorcontrib>Xu, Hockin H.K</creatorcontrib><title>Effect of quaternary ammonium and silver nanoparticle-containing adhesives on dentin bond strength and dental plaque microcosm biofilms</title><title>Dental materials</title><addtitle>Dent Mater</addtitle><description>Abstract Objective Antibacterial bonding agents are promising to hinder the residual and invading bacteria at the tooth–restoration interfaces. The objectives of this study were to develop an antibacterial bonding agent by incorporation of quaternary ammonium dimethacrylate (QADM) and nanoparticles of silver (NAg), and to investigate the effect of QADM-NAg adhesive and primer on dentin bond strength and plaque microcosm biofilm response for the first time. Methods Scotchbond Multi-Purpose adhesive and primer were used as control. Experimental adhesive and primer were made by adding QADM and NAg into control adhesive and primer. Human dentin shear bond strengths were measured ( n = 10). A dental plaque microcosm biofilm model with human saliva as inoculum was used to investigate biofilm metabolic activity, colony-forming unit (CFU) counts, lactic acid production, and live/dead staining assay ( n = 6). Results Adding QADM and NAg into adhesive and primer did not compromise the dentin shear bond strength which ranged from 30 to 35 MPa ( p > 0.1). Scanning electron microscopy (SEM) examinations revealed numerous resin tags, which were similar for the control and the QADM and NAg groups. Adding QADM or NAg markedly reduced the biofilm viability, compared to adhesive control. QADM and NAg together in the adhesive had a much stronger antibacterial effect than using each agent alone ( p < 0.05). Adding QADM and NAg in both adhesive and primer had the strongest antibacterial activity, reducing metabolic activity, CFU, and lactic acid by an order of magnitude, compared to control. Significance Without compromising dentin bond strength and resin tag formation, the QADM and NAg containing adhesive and primer achieved strong antibacterial effects against microcosm biofilms for the first time. QADM-NAg adhesive and primer are promising to combat residual bacteria in tooth cavity and invading bacteria at the margins, thereby to inhibit secondary caries. QADM and NAg incorporation may have a wide applicability to other dental bonding systems.</description><subject>Adhesives</subject><subject>Adult</subject><subject>Advanced Basic Science</subject><subject>Analysis of Variance</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibacterial dental adhesive</subject><subject>Antiinfectives and antibacterials</subject><subject>Bacteria</subject><subject>Biofilms</subject><subject>Biofilms - drug effects</subject><subject>Bonding strength</subject><subject>Caries inhibition</subject><subject>Colony Count, Microbial</subject><subject>Dental Bonding</subject><subject>Dental Leakage - prevention & control</subject><subject>Dental materials</subject><subject>Dental Plaque - metabolism</subject><subject>Dental Stress Analysis</subject><subject>Dentin</subject><subject>Dentin bond strength</subject><subject>Dentin-Bonding Agents - chemistry</subject><subject>Dentin-Bonding Agents - pharmacology</subject><subject>Dentistry</subject><subject>Human saliva microcosm biofilm</subject><subject>Humans</subject><subject>Lactic Acid - metabolism</subject><subject>Materials Testing</subject><subject>Microbial Viability - drug effects</subject><subject>Molar</subject><subject>Nanoparticles</subject><subject>Nanostructure</subject><subject>Quaternary Ammonium Compounds - chemistry</subject><subject>Quaternary Ammonium Compounds - pharmacology</subject><subject>Quaternary ammonium dimethacrylate</subject><subject>Resin Cements - chemistry</subject><subject>Resin Cements - pharmacology</subject><subject>Saliva - microbiology</subject><subject>Shear Strength</subject><subject>Silver Compounds - chemistry</subject><subject>Silver Compounds - pharmacology</subject><subject>Silver nanoparticles</subject><issn>0109-5641</issn><issn>1879-0097</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUstu1DAUtRCIDoU_QMhLNgl2EifxBglVpSBVYgGsLT-uZzw49tRORuoX9LdxOqU8Nqy88D3nnsdF6DUlNSW0f7evDYRZ-rohtKlJV5NmeII2dBx4RQgfnqINoYRXrO_oGXqR854Q0jWcPkdnTcN4Q3u2QXeX1oKecbT4ZpEzpCDTLZbTFINbJiyDwdn5IyQcZIgHmWanPVQ6ltUuuLDF0uwguyNkHANeJbmAVVxxc4KwnXf3JCet-ODlzQJ4cjpFHfOElYvW-Sm_RM-s9BlePbzn6PvHy28Xn6rrL1efLz5cV7qnw1z1auhGLZVS2lrVDZxRa3vTUasoMNMxyQ3wwVqqrOQjwKCHsVHMmr5lPRvac_T-xHtY1ARGF1lJenFIbirGRZRO_P0T3E5s41G0LW_HjhaCtw8EKRYreRaTyxq8lwHikgUl7dgSVqSV0e40WszmnMA-rqFErB2KvTjlItYOBelE6bDA3vwp8RH0q7TfHqAEdXSQRNYOggbjUulSmOj-t-FfAu1LmVr6H3ALeR-Xcga-eBG5YMTX9Y7WM6INIXQN4ieBusor</recordid><startdate>20120801</startdate><enddate>20120801</enddate><creator>Zhang, Ke</creator><creator>Melo, Mary Anne S</creator><creator>Cheng, Lei</creator><creator>Weir, Michael D</creator><creator>Bai, Yuxing</creator><creator>Xu, Hockin H.K</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>FR3</scope><scope>JG9</scope><scope>L7M</scope><scope>5PM</scope></search><sort><creationdate>20120801</creationdate><title>Effect of quaternary ammonium and silver nanoparticle-containing adhesives on dentin bond strength and dental plaque microcosm biofilms</title><author>Zhang, Ke ; Melo, Mary Anne S ; Cheng, Lei ; Weir, Michael D ; Bai, Yuxing ; Xu, Hockin H.K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c617t-6b748cabbbcffb47951ff6d41fb1e5d45a9de97ff1bfa98ee7c782b5fd6356573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adhesives</topic><topic>Adult</topic><topic>Advanced Basic Science</topic><topic>Analysis of Variance</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibacterial dental adhesive</topic><topic>Antiinfectives and antibacterials</topic><topic>Bacteria</topic><topic>Biofilms</topic><topic>Biofilms - drug effects</topic><topic>Bonding strength</topic><topic>Caries inhibition</topic><topic>Colony Count, Microbial</topic><topic>Dental Bonding</topic><topic>Dental Leakage - prevention & control</topic><topic>Dental materials</topic><topic>Dental Plaque - metabolism</topic><topic>Dental Stress Analysis</topic><topic>Dentin</topic><topic>Dentin bond strength</topic><topic>Dentin-Bonding Agents - chemistry</topic><topic>Dentin-Bonding Agents - pharmacology</topic><topic>Dentistry</topic><topic>Human saliva microcosm biofilm</topic><topic>Humans</topic><topic>Lactic Acid - metabolism</topic><topic>Materials Testing</topic><topic>Microbial Viability - drug effects</topic><topic>Molar</topic><topic>Nanoparticles</topic><topic>Nanostructure</topic><topic>Quaternary Ammonium Compounds - chemistry</topic><topic>Quaternary Ammonium Compounds - pharmacology</topic><topic>Quaternary ammonium dimethacrylate</topic><topic>Resin Cements - chemistry</topic><topic>Resin Cements - pharmacology</topic><topic>Saliva - microbiology</topic><topic>Shear Strength</topic><topic>Silver Compounds - chemistry</topic><topic>Silver Compounds - pharmacology</topic><topic>Silver nanoparticles</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Ke</creatorcontrib><creatorcontrib>Melo, Mary Anne S</creatorcontrib><creatorcontrib>Cheng, Lei</creatorcontrib><creatorcontrib>Weir, Michael D</creatorcontrib><creatorcontrib>Bai, Yuxing</creatorcontrib><creatorcontrib>Xu, Hockin H.K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Dental materials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Ke</au><au>Melo, Mary Anne S</au><au>Cheng, Lei</au><au>Weir, Michael D</au><au>Bai, Yuxing</au><au>Xu, Hockin H.K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of quaternary ammonium and silver nanoparticle-containing adhesives on dentin bond strength and dental plaque microcosm biofilms</atitle><jtitle>Dental materials</jtitle><addtitle>Dent Mater</addtitle><date>2012-08-01</date><risdate>2012</risdate><volume>28</volume><issue>8</issue><spage>842</spage><epage>852</epage><pages>842-852</pages><issn>0109-5641</issn><eissn>1879-0097</eissn><abstract>Abstract Objective Antibacterial bonding agents are promising to hinder the residual and invading bacteria at the tooth–restoration interfaces. The objectives of this study were to develop an antibacterial bonding agent by incorporation of quaternary ammonium dimethacrylate (QADM) and nanoparticles of silver (NAg), and to investigate the effect of QADM-NAg adhesive and primer on dentin bond strength and plaque microcosm biofilm response for the first time. Methods Scotchbond Multi-Purpose adhesive and primer were used as control. Experimental adhesive and primer were made by adding QADM and NAg into control adhesive and primer. Human dentin shear bond strengths were measured ( n = 10). A dental plaque microcosm biofilm model with human saliva as inoculum was used to investigate biofilm metabolic activity, colony-forming unit (CFU) counts, lactic acid production, and live/dead staining assay ( n = 6). Results Adding QADM and NAg into adhesive and primer did not compromise the dentin shear bond strength which ranged from 30 to 35 MPa ( p > 0.1). Scanning electron microscopy (SEM) examinations revealed numerous resin tags, which were similar for the control and the QADM and NAg groups. Adding QADM or NAg markedly reduced the biofilm viability, compared to adhesive control. QADM and NAg together in the adhesive had a much stronger antibacterial effect than using each agent alone ( p < 0.05). Adding QADM and NAg in both adhesive and primer had the strongest antibacterial activity, reducing metabolic activity, CFU, and lactic acid by an order of magnitude, compared to control. Significance Without compromising dentin bond strength and resin tag formation, the QADM and NAg containing adhesive and primer achieved strong antibacterial effects against microcosm biofilms for the first time. QADM-NAg adhesive and primer are promising to combat residual bacteria in tooth cavity and invading bacteria at the margins, thereby to inhibit secondary caries. QADM and NAg incorporation may have a wide applicability to other dental bonding systems.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>22592165</pmid><doi>10.1016/j.dental.2012.04.027</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adhesives Adult Advanced Basic Science Analysis of Variance Anti-Bacterial Agents - pharmacology Antibacterial dental adhesive Antiinfectives and antibacterials Bacteria Biofilms Biofilms - drug effects Bonding strength Caries inhibition Colony Count, Microbial Dental Bonding Dental Leakage - prevention & control Dental materials Dental Plaque - metabolism Dental Stress Analysis Dentin Dentin bond strength Dentin-Bonding Agents - chemistry Dentin-Bonding Agents - pharmacology Dentistry Human saliva microcosm biofilm Humans Lactic Acid - metabolism Materials Testing Microbial Viability - drug effects Molar Nanoparticles Nanostructure Quaternary Ammonium Compounds - chemistry Quaternary Ammonium Compounds - pharmacology Quaternary ammonium dimethacrylate Resin Cements - chemistry Resin Cements - pharmacology Saliva - microbiology Shear Strength Silver Compounds - chemistry Silver Compounds - pharmacology Silver nanoparticles |
| title | Effect of quaternary ammonium and silver nanoparticle-containing adhesives on dentin bond strength and dental plaque microcosm biofilms |
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