IFN-γ-producing CD4+ T cells promote experimental cerebral malaria by modulating CD8+ T cell accumulation within the brain

It is well established that IFN-γ is required for the development of experimental cerebral malaria (ECM) during Plasmodium berghei ANKA infection of C57BL/6 mice. However, the temporal and tissue-specific cellular sources of IFN-γ during P. berghei ANKA infection have not been investigated, and it i...

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Veröffentlicht in:	The Journal of immunology (1950) 2012-07, Vol.189 (2), p.968-979
Hauptverfasser:	Villegas-Mendez, Ana, Greig, Rachel, Shaw, Tovah N, de Souza, J Brian, Gwyer Findlay, Emily, Stumhofer, Jason S, Hafalla, Julius C R, Blount, Daniel G, Hunter, Christopher A, Riley, Eleanor M, Couper, Kevin N
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Animals Brain - immunology Brain - parasitology Brain - pathology CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism CD4-Positive T-Lymphocytes - pathology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - pathology Cell Movement - genetics Cell Movement - immunology Disease Models, Animal Female Genetic Predisposition to Disease - genetics Immunity, Innate - genetics Interferon-gamma - biosynthesis Interferon-gamma - deficiency Interferon-gamma - genetics Malaria, Cerebral - immunology Malaria, Cerebral - parasitology Malaria, Cerebral - pathology Male Mice Mice, Inbred C57BL Mice, Knockout Plasmodium berghei Plasmodium berghei - immunology
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