Urinary Levels of Cigarette Smoke Constituent Metabolites Are Prospectively Associated with Lung Cancer Development in Smokers

Polycyclic aromatic hydrocarbons (PAH) are believed to be among the principal causative agents for lung cancer in smokers, but no epidemiologic studies have evaluated the relationship of PAH uptake and metabolism to lung cancer. In this study, we quantified prediagnostic urinary levels of r-1,t-2,3,...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2011-11, Vol.71 (21), p.6749-6757
Hauptverfasser:	YUAN, Jian-Min, GAO, Yu-Tang, SHAOMEI HAN, NELSON, Heather H, YU, Mirni C, HECHT, Stephen S, MURPHY, Sharon E, CARMELLA, Steven G, RENWEI WANG, YAN ZHONG, MOY, Kristin A, DAVIS, Andrew B, LI TAO, MENGLAN CHEN
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antineoplastic agents Biological and medical sciences China - epidemiology Cotinine - urine Female Humans Lung Neoplasms - epidemiology Lung Neoplasms - etiology Lung Neoplasms - urine Male Medical sciences Middle Aged Nicotiana Nicotine - pharmacokinetics Nitrosamines - pharmacokinetics Nitrosamines - urine Pharmacology. Drug treatments Phenanthrenes - urine Pneumology Prospective Studies Pyridines - urine Smoke - adverse effects Smoke - analysis Smoking - adverse effects Tobacco, tobacco smoking Toxicology Tumors Tumors of the respiratory system and mediastinum
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