Catestatin (Chromogranin A352–372) and Novel Effects on Mobilization of Fat from Adipose Tissue through Regulation of Adrenergic and Leptin Signaling

Chromogranin A knock-out (Chga-KO) mice display increased adiposity despite high levels of circulating catecholamines and leptin. Consistent with diet-induced obese mice, desensitization of leptin receptors caused by hyperleptinemia is believed to contribute to the obese phenotype of these KO mice....

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Veröffentlicht in:	The Journal of biological chemistry 2012-06, Vol.287 (27), p.23141-23151
Hauptverfasser:	Bandyopadhyay, Gautam K., Vu, Christine U., Gentile, Stefano, Lee, Howon, Biswas, Nilima, Chi, Nai-Wen, O'Connor, Daniel T., Mahata, Sushil K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes - cytology Adipocytes - drug effects Adipocytes - metabolism Adipose Tissue - cytology Adipose Tissue - drug effects Adipose Tissue - metabolism Adrenergic Receptor Animals Anti-Obesity Agents - metabolism Anti-Obesity Agents - pharmacology Catecholamines Catecholamines - metabolism Chromogranin A - genetics Chromogranin A - metabolism Chromogranin A - pharmacology Fatty Acids - blood Fatty Acids - metabolism Gene Expression - drug effects Gene Expression - physiology Leptin - metabolism Leptin Receptor Lipids Lipolysis - drug effects Lipolysis - physiology Male Mice Mice, 129 Strain Mice, Inbred C57BL Mice, Knockout Mice, Obese Obesity - drug therapy Obesity - genetics Obesity - metabolism Peptide Fragments - metabolism Peptide Fragments - pharmacology Primary Cell Culture Receptors, Adrenergic, alpha - metabolism Signal Transduction - drug effects Signal Transduction - physiology
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