Protective Role of Cell Division Cycle 48 (CDC48) Protein against Neurodegeneration via Ubiquitin-Proteasome System Dysfunction during Zebrafish Development

Cell division cycle 48 (CDC48), a ubiquitin-dependent molecular chaperone, is thought to mediate a variety of degradative and regulatory processes and maintain cellular homoeostasis. To investigate the protective function of CDC48 against accumulated ubiquitinated proteins during neurodevelopment, w...

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Veröffentlicht in:	The Journal of biological chemistry 2012-06, Vol.287 (27), p.23047-23056
Hauptverfasser:	Imamura, Shintaro, Yabu, Takeshi, Yamashita, Michiaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - chemistry Adenosine Triphosphatases - genetics Adenosine Triphosphatases - metabolism Animals Autophagy CDC48 Cell Cycle Proteins - chemistry Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Division - physiology Development Diencephalon - abnormalities Diencephalon - metabolism Gene Expression Regulation, Developmental - physiology Gene Expression Regulation, Enzymologic - physiology Mesencephalon - abnormalities Mesencephalon - metabolism Molecular Chaperone Motor Neurons - cytology Motor Neurons - metabolism Nerve Degeneration - metabolism Nerve Degeneration - physiopathology Neurodegeneration p97 Phenotype Proteasome Proteasome Endopeptidase Complex - metabolism Protein Structure, Tertiary Protein Synthesis and Degradation Retinal Ganglion Cells - cytology Retinal Ganglion Cells - enzymology Spinal Cord - abnormalities Spinal Cord - metabolism Ubiquitin - metabolism Ubiquitination Valosin Containing Protein VCP Zebrafish Zebrafish - embryology Zebrafish - genetics Zebrafish - metabolism
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