Neural Transmembrane Protease and Endothelial Gs Protein Activation in Cell Contact-dependent Signaling between Neural Stem/Progenitor Cells and Brain Endothelial Cells

Vasculature is an important component of the neural stem cell niche in brain. It regulates neural stem/progenitor (NS/P) cell self-renewal, differentiation, and migration. In the neurogenic niches of adult brain, NS/P cells lie close to blood vessels, and proliferating NS/P cells frequently contact...

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Veröffentlicht in:	The Journal of biological chemistry 2012-06, Vol.287 (27), p.22497-22508
Hauptverfasser:	Tung, Hsiu-Hui, Lee, Sheau-Ling
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - blood supply Brain - cytology Cell Biology Cell Communication - physiology Cell Differentiation - drug effects Cell Differentiation - physiology Cell Movement - physiology Cells, Cultured Chemokines - metabolism Coculture Techniques Culture Media, Conditioned - pharmacology Cytokine Induction Cytokines - metabolism Endothelial Cell Endothelial Cells - cytology Endothelial Cells - metabolism Ependyma - blood supply Ependyma - cytology G Protein-coupled Receptors (GPCR) Green Fluorescent Proteins - genetics GTP-Binding Protein alpha Subunits, Gs - metabolism GTP-Binding Proteins - metabolism GTPase Interleukin-6 - pharmacology Male MAP Kinase Signaling System - physiology Matriptase/Epithin Mice Mice, Inbred Strains Mice, Mutant Strains Neural Progenitor Cells Neural Stem Cell Neural Stem Cells - cytology Neural Stem Cells - metabolism Neurovasculature Niche p38 Mitogen-Activated Protein Kinases - metabolism Stem Cell Niche - physiology Type II Transmembrane Serine Protease
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