Misfolded Gβ is recruited to cytoplasmic dynein by Nudel for efficient clearance

The Gβγ heterodimer is an important signal transducer. Gβ, however, is prone to misfoiding due to its requirement for GT and chaperones for proper folding. How cells dispose of misfolded Gβ （mfGβ） is not clear. Here, we showed that mfGβ was able to be polyubiquitinated and subsequently degraded by t...

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Veröffentlicht in:	Cell research 2012-07, Vol.22 (7), p.1140-1154
Hauptverfasser:	Wan, Yihan, Yang, Zhenye, Guo, Jing, Zhang, Qiangge, Zeng, Liyong, Song, Wei, Xiao, Yue, Zhu, Xueliang
Format:	Artikel
Sprache:	eng
Schlagworte:	631/80/2023 631/80/474 631/80/86 Animals Biomedical and Life Sciences Carrier Proteins - genetics Carrier Proteins - metabolism Cell Biology Cell Line Centrosome - metabolism Cercopithecus aethiops COS Cells Cytoplasmic Dyneins - genetics Cytoplasmic Dyneins - metabolism GTP-Binding Protein beta Subunits - genetics GTP-Binding Protein beta Subunits - metabolism HeLa Cells Humans Immunoblotting Immunoprecipitation Leupeptins - pharmacology Life Sciences Microscopy, Fluorescence Original original-article Protein Binding - drug effects Protein Folding - drug effects Protein Transport - drug effects 信号转导动力蛋白招聘细胞内胞质蛋白酶体抑制剂通关错误折叠
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