Sox4 cooperates with CREB in myeloid transformation

The cAMP response element-binding protein (CREB) is a nuclear transcription factor that is critical for normal and neoplastic hematopoiesis. Previous studies have demonstrated that CREB is a proto-oncogene whose overexpression promotes cellular proliferation in hematopoietic cells. Transgenic mice t...

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Veröffentlicht in:	Blood 2012-07, Vol.120 (1), p.155-165
Hauptverfasser:	Sandoval, Salemiz, Kraus, Christina, Cho, Er-Chieh, Cho, Michelle, Bies, Juraj, Manara, Elena, Accordi, Benedetta, Landaw, Elliot M., Wolff, Linda, Pigazzi, Martina, Sakamoto, Kathleen M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Bone Marrow Cells - cytology Bone Marrow Cells - metabolism Cell Proliferation Cell Transformation, Neoplastic - metabolism Cyclic AMP Response Element-Binding Protein - genetics Cyclic AMP Response Element-Binding Protein - metabolism Female Hematologic and hematopoietic diseases HL-60 Cells Humans K562 Cells Leukemia, Myeloid, Acute - metabolism Leukemia, Myeloid, Acute - pathology Medical sciences Mice Mice, Inbred C57BL Mice, Transgenic Myeloid Cells - cytology Myeloid Cells - metabolism Myeloid Neoplasia Phosphorylation - physiology Pregnancy Retroviridae - genetics SOXC Transcription Factors - metabolism
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