Perilipin 5, a Lipid Droplet-binding Protein, Protects Heart from Oxidative Burden by Sequestering Fatty Acid from Excessive Oxidation

Lipid droplets (LDs) are ubiquitous organelles storing neutral lipids, including triacylglycerol (TAG) and cholesterol ester. The properties of LDs vary greatly among tissues, and LD-binding proteins, the perilipin family in particular, play critical roles in determining such diversity. Overaccumula...

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Veröffentlicht in:	The Journal of biological chemistry 2012-07, Vol.287 (28), p.23852-23863
Hauptverfasser:	Kuramoto, Kenta, Okamura, Tomoo, Yamaguchi, Tomohiro, Nakamura, Tomoe Y., Wakabayashi, Shigeo, Morinaga, Hidetaka, Nomura, Masatoshi, Yanase, Toshihiko, Otsu, Kinya, Usuda, Nobuteru, Matsumura, Shigenobu, Inoue, Kazuo, Fushiki, Tohru, Kojima, Yumiko, Hashimoto, Takeshi, Sakai, Fumie, Hirose, Fumiko, Osumi, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - pharmacology Animals Animals, Newborn Cells, Cultured Cytoplasmic Granules - metabolism Cytoplasmic Granules - ultrastructure Fatty Acid Oxidation Fatty Acids - metabolism Female Free Radical Scavengers - pharmacology Heart Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Lipase - metabolism Lipid Droplet Lipid Metabolism Lipids Male Mice Mice, Inbred C57BL Mice, Knockout Microscopy, Electron Muscle Proteins - genetics Muscle Proteins - metabolism Myocardium - cytology Myocardium - metabolism Myocardium - ultrastructure Myocytes, Cardiac - cytology Myocytes, Cardiac - metabolism Oxidation-Reduction - drug effects Oxidative Stress Perilipin Family Reactive Oxygen Species (ROS) Reactive Oxygen Species - metabolism Triacylglycerol Triglycerides - metabolism
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