Inefficient Reprogramming of Fibroblasts into Cardiomyocytes Using Gata4, Mef2c, and Tbx5

RATIONALE:Direct reprogramming of fibroblasts into cardiomyocytes is a novel strategy for cardiac regeneration. However, the key determinants involved in this process are unknown. OBJECTIVE:To assess the efficiency of direct fibroblast reprogramming via viral overexpression of GATA4, Mef2c, and Tbx5...

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Veröffentlicht in:	Circulation research 2012-06, Vol.111 (1), p.50-55
Hauptverfasser:	Chen, Jenny X, Krane, Markus, Deutsch, Marcus-Andre, Wang, Li, Rav-Acha, Moshe, Gregoire, Serge, Engels, Marc C, Rajarajan, Kuppusamy, Karra, Ravi, Abel, E Dale, Wu, Joe C, Milan, David, Wu, Sean M
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials Animals Biological and medical sciences Cardiology. Vascular system Cell Lineage Cell Survival Cell Transdifferentiation - drug effects Coronary heart disease Female Fibroblasts - metabolism Fibroblasts - transplantation Fundamental and applied biological sciences. Psychology GATA4 Transcription Factor - genetics GATA4 Transcription Factor - metabolism Gene Expression Regulation, Developmental Genes, Reporter Genotype Heart HEK293 Cells Humans Male Medical sciences MEF2 Transcription Factors Mice Mice, SCID Mice, Transgenic Myocarditis. Cardiomyopathies Myocytes, Cardiac - metabolism Myocytes, Cardiac - transplantation Myogenic Regulatory Factors - genetics Myogenic Regulatory Factors - metabolism Patch-Clamp Techniques Phenotype Polymerase Chain Reaction T-Box Domain Proteins - genetics T-Box Domain Proteins - metabolism Time Factors Transcription, Genetic Transfection Up-Regulation Vertebrates: cardiovascular system
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