The relationships between cellular components of the peritumoural inflammatory response, clinicopathological characteristics and survival in patients with primary operable colorectal cancer
Background: The host inflammatory response is an important determinant of cancer outcome. We examined different methods of assessing the local inflammatory response in colorectal tumours and explored relationships with both clinicopathological characteristics and survival. Methods: Cohort study of p...
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| Veröffentlicht in: | British journal of cancer 2012-06, Vol.106 (12), p.2010-2015 |
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| creator | Richards, C H Flegg, K M SD Roxburgh, C Going, J J Mohammed, Z Horgan, P G McMillan, D C |
| description | Background:
The host inflammatory response is an important determinant of cancer outcome. We examined different methods of assessing the local inflammatory response in colorectal tumours and explored relationships with both clinicopathological characteristics and survival.
Methods:
Cohort study of patients (
n
=130) with primary operable colorectal cancer and mature follow-up. Local inflammatory response at the invasive margin was assessed with: (1) a semi-quantitative assessment of peritumoural inflammation using Klintrup–Makinen (K–M) grading and (2) an assessment of individual immune cell infiltration (lymphocytes, plasma cells, neutrophils, macrophages and eosinophils).
Results:
The peritumoural inflammatory response was K–M low grade in 48% and high grade in 52%. Inflammatory cells were primarily macrophages, lymphocytes and neutrophils with relatively few plasma cells or eosinophils. On univariate analysis, K–M grade, lymphocyte infiltration and plasma cell infiltration were associated with cancer-specific survival. On multivariate analysis, only systemic inflammatory response, TNM (tumour, node and metastases) stage, venous invasion, tumour necrosis and K–M grade were independently associated with cancer-specific survival. There was no relationship between local infiltration of inflammatory cells and a systemic inflammatory response. However, high K–M grade, lymphocyte infiltration and plasma cell infiltration were associated with a number of favourable pathological characteristics, including an absence of venous invasion.
Conclusion:
Infiltration of inflammatory cells in the invasive margin of colorectal tumours is beneficial to survival. The adaptive immune response appears to have a prominent role in the prevention of tumour progression in patients with colorectal cancer. |
| doi_str_mv | 10.1038/bjc.2012.211 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3388572</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1024098376</sourcerecordid><originalsourceid>FETCH-LOGICAL-c480t-d1b32cf201e95d63be2a71645e65f8affdb35c742a9a6bb7ede5cb718f9935e63</originalsourceid><addsrcrecordid>eNptkktv1DAQxyMEokvhxhlZQkgcmsWPzetSCVXlIVXiUs6W40w2Xjl2sJ2t-HB8t052l1IQJ8ua3_znP48se83omlFRf2h3es0p42vO2JNsxQrBc1bz6mm2opRWOW04PctexLjDb0Pr6nl2xnnRlFzUq-zX7QAkgFXJeBcHM0XSQroDcESDtbNVgWg_Tt6BS5H4niRMmCCYNI9-DsoS43qrxlElH36iVEQ2wgXR1jij_aTS4K3fGo2oHlRQOmF2TEZHolxH4hz2Zn_QIQibQ507kwYyBTMq1PRYTrUW0Ij1AXRalJTTEF5mz3plI7w6vefZ90_Xt1df8ptvn79efbzJ9aamKe9YK7jucUrQFF0pWuCqYuWmgLLoa9X3XSsKXW24alTZthV0UOi2YnXfNAIhcZ5dHnWnuR2h0-gRO5cng9IrI_-OODPIrd9LIeq6qDgKvD8JBP9jhpjkaOIyYOXAz1Eyyje0qUW11Hr7D7rDOTtsTy77FoLRZoPUxZHSwccYoH8ww-iBk3gXcrkLiXeB-JvHDTzAvw8BgXcnQEXcVB9wvib-4UpKRUEL5PIjFzHkthAeu_tP4XuZ1dd3</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1038331094</pqid></control><display><type>article</type><title>The relationships between cellular components of the peritumoural inflammatory response, clinicopathological characteristics and survival in patients with primary operable colorectal cancer</title><source>MEDLINE</source><source>Nature Journals Online</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>SpringerLink Journals - AutoHoldings</source><creator>Richards, C H ; Flegg, K M ; SD Roxburgh, C ; Going, J J ; Mohammed, Z ; Horgan, P G ; McMillan, D C</creator><creatorcontrib>Richards, C H ; Flegg, K M ; SD Roxburgh, C ; Going, J J ; Mohammed, Z ; Horgan, P G ; McMillan, D C</creatorcontrib><description>Background:
The host inflammatory response is an important determinant of cancer outcome. We examined different methods of assessing the local inflammatory response in colorectal tumours and explored relationships with both clinicopathological characteristics and survival.
Methods:
Cohort study of patients (
n
=130) with primary operable colorectal cancer and mature follow-up. Local inflammatory response at the invasive margin was assessed with: (1) a semi-quantitative assessment of peritumoural inflammation using Klintrup–Makinen (K–M) grading and (2) an assessment of individual immune cell infiltration (lymphocytes, plasma cells, neutrophils, macrophages and eosinophils).
Results:
The peritumoural inflammatory response was K–M low grade in 48% and high grade in 52%. Inflammatory cells were primarily macrophages, lymphocytes and neutrophils with relatively few plasma cells or eosinophils. On univariate analysis, K–M grade, lymphocyte infiltration and plasma cell infiltration were associated with cancer-specific survival. On multivariate analysis, only systemic inflammatory response, TNM (tumour, node and metastases) stage, venous invasion, tumour necrosis and K–M grade were independently associated with cancer-specific survival. There was no relationship between local infiltration of inflammatory cells and a systemic inflammatory response. However, high K–M grade, lymphocyte infiltration and plasma cell infiltration were associated with a number of favourable pathological characteristics, including an absence of venous invasion.
Conclusion:
Infiltration of inflammatory cells in the invasive margin of colorectal tumours is beneficial to survival. The adaptive immune response appears to have a prominent role in the prevention of tumour progression in patients with colorectal cancer.</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/bjc.2012.211</identifier><identifier>PMID: 22596238</identifier><identifier>CODEN: BJCAAI</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/250/2152 ; 631/250/256 ; 692/699/67/1504/1885 ; 692/700/1750 ; Anemia ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Colorectal cancer ; Colorectal Neoplasms - immunology ; Colorectal Neoplasms - mortality ; Colorectal Neoplasms - pathology ; Drug Resistance ; Eosinophils - immunology ; Epidemiology ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Hemoglobin ; Humans ; Inflammation ; Inflammation - diagnosis ; Leukocyte Count ; Lymphocytes ; Lymphocytes, Tumor-Infiltrating - immunology ; Macrophages - immunology ; Male ; Medical research ; Medical sciences ; Metastasis ; Molecular Diagnostics ; Molecular Medicine ; Neoplasm Invasiveness ; Neutrophils ; Neutrophils - immunology ; Oncology ; Plasma ; Plasma Cells - immunology ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Surgery ; Tumors</subject><ispartof>British journal of cancer, 2012-06, Vol.106 (12), p.2010-2015</ispartof><rights>The Author(s) 2012</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Jun 5, 2012</rights><rights>Copyright © 2012 Cancer Research UK 2012 Cancer Research UK</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c480t-d1b32cf201e95d63be2a71645e65f8affdb35c742a9a6bb7ede5cb718f9935e63</citedby><cites>FETCH-LOGICAL-c480t-d1b32cf201e95d63be2a71645e65f8affdb35c742a9a6bb7ede5cb718f9935e63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388572/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388572/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26003505$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22596238$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Richards, C H</creatorcontrib><creatorcontrib>Flegg, K M</creatorcontrib><creatorcontrib>SD Roxburgh, C</creatorcontrib><creatorcontrib>Going, J J</creatorcontrib><creatorcontrib>Mohammed, Z</creatorcontrib><creatorcontrib>Horgan, P G</creatorcontrib><creatorcontrib>McMillan, D C</creatorcontrib><title>The relationships between cellular components of the peritumoural inflammatory response, clinicopathological characteristics and survival in patients with primary operable colorectal cancer</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>Background:
The host inflammatory response is an important determinant of cancer outcome. We examined different methods of assessing the local inflammatory response in colorectal tumours and explored relationships with both clinicopathological characteristics and survival.
Methods:
Cohort study of patients (
n
=130) with primary operable colorectal cancer and mature follow-up. Local inflammatory response at the invasive margin was assessed with: (1) a semi-quantitative assessment of peritumoural inflammation using Klintrup–Makinen (K–M) grading and (2) an assessment of individual immune cell infiltration (lymphocytes, plasma cells, neutrophils, macrophages and eosinophils).
Results:
The peritumoural inflammatory response was K–M low grade in 48% and high grade in 52%. Inflammatory cells were primarily macrophages, lymphocytes and neutrophils with relatively few plasma cells or eosinophils. On univariate analysis, K–M grade, lymphocyte infiltration and plasma cell infiltration were associated with cancer-specific survival. On multivariate analysis, only systemic inflammatory response, TNM (tumour, node and metastases) stage, venous invasion, tumour necrosis and K–M grade were independently associated with cancer-specific survival. There was no relationship between local infiltration of inflammatory cells and a systemic inflammatory response. However, high K–M grade, lymphocyte infiltration and plasma cell infiltration were associated with a number of favourable pathological characteristics, including an absence of venous invasion.
Conclusion:
Infiltration of inflammatory cells in the invasive margin of colorectal tumours is beneficial to survival. The adaptive immune response appears to have a prominent role in the prevention of tumour progression in patients with colorectal cancer.</description><subject>631/250/2152</subject><subject>631/250/256</subject><subject>692/699/67/1504/1885</subject><subject>692/700/1750</subject><subject>Anemia</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Colorectal cancer</subject><subject>Colorectal Neoplasms - immunology</subject><subject>Colorectal Neoplasms - mortality</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Drug Resistance</subject><subject>Eosinophils - immunology</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Hemoglobin</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammation - diagnosis</subject><subject>Leukocyte Count</subject><subject>Lymphocytes</subject><subject>Lymphocytes, Tumor-Infiltrating - immunology</subject><subject>Macrophages - immunology</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Metastasis</subject><subject>Molecular Diagnostics</subject><subject>Molecular Medicine</subject><subject>Neoplasm Invasiveness</subject><subject>Neutrophils</subject><subject>Neutrophils - immunology</subject><subject>Oncology</subject><subject>Plasma</subject><subject>Plasma Cells - immunology</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Surgery</subject><subject>Tumors</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNptkktv1DAQxyMEokvhxhlZQkgcmsWPzetSCVXlIVXiUs6W40w2Xjl2sJ2t-HB8t052l1IQJ8ua3_znP48se83omlFRf2h3es0p42vO2JNsxQrBc1bz6mm2opRWOW04PctexLjDb0Pr6nl2xnnRlFzUq-zX7QAkgFXJeBcHM0XSQroDcESDtbNVgWg_Tt6BS5H4niRMmCCYNI9-DsoS43qrxlElH36iVEQ2wgXR1jij_aTS4K3fGo2oHlRQOmF2TEZHolxH4hz2Zn_QIQibQ507kwYyBTMq1PRYTrUW0Ij1AXRalJTTEF5mz3plI7w6vefZ90_Xt1df8ptvn79efbzJ9aamKe9YK7jucUrQFF0pWuCqYuWmgLLoa9X3XSsKXW24alTZthV0UOi2YnXfNAIhcZ5dHnWnuR2h0-gRO5cng9IrI_-OODPIrd9LIeq6qDgKvD8JBP9jhpjkaOIyYOXAz1Eyyje0qUW11Hr7D7rDOTtsTy77FoLRZoPUxZHSwccYoH8ww-iBk3gXcrkLiXeB-JvHDTzAvw8BgXcnQEXcVB9wvib-4UpKRUEL5PIjFzHkthAeu_tP4XuZ1dd3</recordid><startdate>20120605</startdate><enddate>20120605</enddate><creator>Richards, C H</creator><creator>Flegg, K M</creator><creator>SD Roxburgh, C</creator><creator>Going, J J</creator><creator>Mohammed, Z</creator><creator>Horgan, P G</creator><creator>McMillan, D C</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20120605</creationdate><title>The relationships between cellular components of the peritumoural inflammatory response, clinicopathological characteristics and survival in patients with primary operable colorectal cancer</title><author>Richards, C H ; Flegg, K M ; SD Roxburgh, C ; Going, J J ; Mohammed, Z ; Horgan, P G ; McMillan, D C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c480t-d1b32cf201e95d63be2a71645e65f8affdb35c742a9a6bb7ede5cb718f9935e63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>631/250/2152</topic><topic>631/250/256</topic><topic>692/699/67/1504/1885</topic><topic>692/700/1750</topic><topic>Anemia</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Colorectal cancer</topic><topic>Colorectal Neoplasms - immunology</topic><topic>Colorectal Neoplasms - mortality</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Drug Resistance</topic><topic>Eosinophils - immunology</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Hemoglobin</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Inflammation - diagnosis</topic><topic>Leukocyte Count</topic><topic>Lymphocytes</topic><topic>Lymphocytes, Tumor-Infiltrating - immunology</topic><topic>Macrophages - immunology</topic><topic>Male</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Metastasis</topic><topic>Molecular Diagnostics</topic><topic>Molecular Medicine</topic><topic>Neoplasm Invasiveness</topic><topic>Neutrophils</topic><topic>Neutrophils - immunology</topic><topic>Oncology</topic><topic>Plasma</topic><topic>Plasma Cells - immunology</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Surgery</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Richards, C H</creatorcontrib><creatorcontrib>Flegg, K M</creatorcontrib><creatorcontrib>SD Roxburgh, C</creatorcontrib><creatorcontrib>Going, J J</creatorcontrib><creatorcontrib>Mohammed, Z</creatorcontrib><creatorcontrib>Horgan, P G</creatorcontrib><creatorcontrib>McMillan, D C</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Richards, C H</au><au>Flegg, K M</au><au>SD Roxburgh, C</au><au>Going, J J</au><au>Mohammed, Z</au><au>Horgan, P G</au><au>McMillan, D C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The relationships between cellular components of the peritumoural inflammatory response, clinicopathological characteristics and survival in patients with primary operable colorectal cancer</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>2012-06-05</date><risdate>2012</risdate><volume>106</volume><issue>12</issue><spage>2010</spage><epage>2015</epage><pages>2010-2015</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><coden>BJCAAI</coden><abstract>Background:
The host inflammatory response is an important determinant of cancer outcome. We examined different methods of assessing the local inflammatory response in colorectal tumours and explored relationships with both clinicopathological characteristics and survival.
Methods:
Cohort study of patients (
n
=130) with primary operable colorectal cancer and mature follow-up. Local inflammatory response at the invasive margin was assessed with: (1) a semi-quantitative assessment of peritumoural inflammation using Klintrup–Makinen (K–M) grading and (2) an assessment of individual immune cell infiltration (lymphocytes, plasma cells, neutrophils, macrophages and eosinophils).
Results:
The peritumoural inflammatory response was K–M low grade in 48% and high grade in 52%. Inflammatory cells were primarily macrophages, lymphocytes and neutrophils with relatively few plasma cells or eosinophils. On univariate analysis, K–M grade, lymphocyte infiltration and plasma cell infiltration were associated with cancer-specific survival. On multivariate analysis, only systemic inflammatory response, TNM (tumour, node and metastases) stage, venous invasion, tumour necrosis and K–M grade were independently associated with cancer-specific survival. There was no relationship between local infiltration of inflammatory cells and a systemic inflammatory response. However, high K–M grade, lymphocyte infiltration and plasma cell infiltration were associated with a number of favourable pathological characteristics, including an absence of venous invasion.
Conclusion:
Infiltration of inflammatory cells in the invasive margin of colorectal tumours is beneficial to survival. The adaptive immune response appears to have a prominent role in the prevention of tumour progression in patients with colorectal cancer.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>22596238</pmid><doi>10.1038/bjc.2012.211</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of cancer, 2012-06, Vol.106 (12), p.2010-2015 |
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| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3388572 |
| source | MEDLINE; Nature Journals Online; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; SpringerLink Journals - AutoHoldings |
| subjects | 631/250/2152 631/250/256 692/699/67/1504/1885 692/700/1750 Anemia Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Colorectal cancer Colorectal Neoplasms - immunology Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology Drug Resistance Eosinophils - immunology Epidemiology Female Gastroenterology. Liver. Pancreas. Abdomen Hemoglobin Humans Inflammation Inflammation - diagnosis Leukocyte Count Lymphocytes Lymphocytes, Tumor-Infiltrating - immunology Macrophages - immunology Male Medical research Medical sciences Metastasis Molecular Diagnostics Molecular Medicine Neoplasm Invasiveness Neutrophils Neutrophils - immunology Oncology Plasma Plasma Cells - immunology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Surgery Tumors |
| title | The relationships between cellular components of the peritumoural inflammatory response, clinicopathological characteristics and survival in patients with primary operable colorectal cancer |
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