Laser microdissection and mass spectrometry–based proteomics aids the diagnosis and typing of renal amyloidosis

Accurate diagnosis and typing of renal amyloidosis is critical for prognosis, genetic counseling, and treatment. Laser microdissection and mass spectrometry are emerging techniques for the analysis and diagnosis of many renal diseases. Here we present the results of laser microdissection and mass sp...

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Veröffentlicht in:	Kidney international 2012-07, Vol.82 (2), p.226-234
Hauptverfasser:	Sethi, Sanjeev, Vrana, Julie A., Theis, Jason D., Leung, Nelson, Sethi, Anjali, Nasr, Samih H., Fervenza, Fernando C., Cornell, Lynn D., Fidler, Mary E., Dogan, Ahmet
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Amino Acid Sequence Amyloid amyloid typing Amyloidosis Amyloidosis - classification Amyloidosis - diagnosis Amyloidosis - immunology Amyloidosis - metabolism Apolipoprotein A-I Biological and medical sciences Biomarkers - analysis Biopsy Case-Control Studies Deposits Gelsolin Human viral diseases Humans Immunoglobulins Infectious diseases Kidney Kidney diseases Kidney Diseases - classification Kidney Diseases - diagnosis Kidney Diseases - immunology Kidney Diseases - metabolism Kidney Glomerulus - chemistry Kidney Glomerulus - immunology Laser Capture Microdissection laser microdissection Lasers Leukocytes mass spectrometry Mass spectroscopy Medical sciences Minnesota Molecular Sequence Data Nephrology. Urinary tract diseases Original Predictive Value of Tests Prognosis Proteins - analysis proteomics Proteomics - methods Sequence Analysis, Protein Spectrometry, Mass, Electrospray Ionization Tandem Mass Spectrometry transthyretin Typing Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
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