Permanent protection of PLG scaffold transplanted allogeneic islet grafts in diabetic mice treated with ECDI-fixed donor splenocyte infusions

Abstract Allogeneic islet cell transplantation is a promising treatment for human type 1 diabetes. Currently, human islets are transplanted via intra-portal infusions. While successful, it leads to significant early islet attrition from instant blood-mediated inflammatory reaction. An extra-hepatic...

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Veröffentlicht in:	Biomaterials 2011-07, Vol.32 (20), p.4517-4524
Hauptverfasser:	Kheradmand, Taba, Wang, Shusen, Gibly, Romie F, Zhang, Xiaomin, Holland, Samantha, Tasch, James, Graham, Jack G, Kaufman, Dixon B, Miller, Stephen D, Shea, Lonnie D, Luo, Xunrong
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Allogeneic cell Animals Biocompatible Materials - chemistry Biocompatible Materials - metabolism Carbodiimides - chemistry Dentistry Diabetes Mellitus, Experimental Diabetes Mellitus, Type 1 - surgery Humans Immune Tolerance Islet Islets of Langerhans Transplantation - immunology Islets of Langerhans Transplantation - methods Male Materials Testing Mice Mice, Inbred BALB C Mice, Inbred C57BL Poly(lactide-co-glycolide) (PLG) Polyglactin 910 - chemistry Scaffold Spleen - cytology Tissue Scaffolds - chemistry Tolerance Transplantation Transplantation, Homologous
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