FGF23 neutralization improves chronic kidney disease-associated hyperparathyroidism yet increases mortality

Chronic kidney disease-mineral and bone disorder (CKD-MBD) is associated with secondary hyperparathyroidism (HPT) and serum elevations in the phosphaturic hormone FGF23, which may be maladaptive and lead to increased morbidity and mortality. To determine the role of FGF23 in the pathogenesis of CKD-...

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Veröffentlicht in:	The Journal of clinical investigation 2012-07, Vol.122 (7), p.2543-2553
Hauptverfasser:	Shalhoub, Victoria, Shatzen, Edward M, Ward, Sabrina C, Davis, James, Stevens, Jennitte, Bi, Vivian, Renshaw, Lisa, Hawkins, Nessa, Wang, Wei, Chen, Ching, Tsai, Mei-Mei, Cattley, Russell C, Wronski, Thomas J, Xia, Xuechen, Li, Xiaodong, Henley, Charles, Eschenberg, Michael, Richards, William G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal, Murine-Derived - pharmacology Aorta - pathology Biomarkers - metabolism Biomedical research Bone diseases Calcification Calcitriol - blood Calcium - blood Cardiovascular disease CHO Cells Chronic Kidney Disease-Mineral and Bone Disorder - blood Chronic Kidney Disease-Mineral and Bone Disorder - metabolism Chronic Kidney Disease-Mineral and Bone Disorder - physiopathology Complications and side effects Cricetinae Development and progression Fibroblast Growth Factors - antagonists & inhibitors Fibroblast Growth Factors - immunology Fibroblast Growth Factors - metabolism Genes, Reporter Glomerular Filtration Rate Health aspects Hemodynamics Hyperparathyroidism Hyperparathyroidism, Secondary - blood Hyperparathyroidism, Secondary - metabolism Hyperparathyroidism, Secondary - physiopathology Kidney - pathology Kidney - physiopathology Kidney diseases Luciferases - biosynthesis Luciferases - genetics Male Mice Mice, Inbred BALB C Mortality Myocardium - pathology Parathyroid Hormone - blood Phosphates - blood Rats Rats, Sprague-Dawley Renal Insufficiency, Chronic - blood Renal Insufficiency, Chronic - metabolism Renal Insufficiency, Chronic - physiopathology Risk factors Tibia - metabolism Tibia - pathology United States Vascular Calcification - pathology Vitamin D
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