A novel isoform of the 8p22 tumor suppressor gene DLC1 suppresses tumor growth and is frequently silenced in multiple common tumors

The critical 8p22 tumor suppressor deleted in liver cancer 1 ( DLC1 ) is frequently inactivated by aberrant CpG methylation and/or genetic deletion and implicated in tumorigeneses of multiple tumor types. Here, we report the identification and characterization of its new isoform, DLC1 isoform 4 ( DL...

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Veröffentlicht in:	Oncogene 2011-04, Vol.30 (16), p.1923-1935
Hauptverfasser:	Low, J S W, Tao, Q, Ng, K M, Goh, H K, Shu, X-S, Woo, W L, Ambinder, R F, Srivastava, G, Shamay, M, Chan, A T C, Popescu, N C, Hsieh, W-S
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/2489/2487/2486 631/67/581 Apoptosis Base Sequence Biological and medical sciences Breast Carcinogenesis Cell Biology Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cellular biology Cervix Chromosome 8 Chromosomes, Human, Pair 8 CpG islands Demethylation DNA Methylation DNA Primers DNMT1 protein Ectopic expression Epigenetics Epithelial cells Esophagus Fundamental and applied biological sciences. Psychology Gene expression Gene Silencing Genes, Tumor Suppressor Genetic aspects GTPase-Activating Proteins - genetics Health aspects Human Genetics Humans Internal Medicine Isoforms Liver cancer Lung carcinoma Medicine Medicine & Public Health Methyltransferases Molecular and cellular biology Molecular Sequence Data Multiple primary tumors N-Terminus Neoplasms - genetics Neoplasms - pathology Oncology original-article p53 Protein Physiological aspects Transcription Tumor cell lines Tumor cells Tumor suppressor genes Tumor Suppressor Proteins - genetics Tumors
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