Cooperative Tertiary Interaction Network Guides RNA Folding

Noncoding RNAs form unique 3D structures, which perform many regulatory functions. To understand how RNAs fold uniquely despite a small number of tertiary interaction motifs, we mutated the major tertiary interactions in a group I ribozyme by single-base substitutions. The resulting perturbations to...

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Veröffentlicht in:	Cell 2012-04, Vol.149 (2), p.348-357
Hauptverfasser:	Behrouzi, Reza, Roh, Joon Ho, Kilburn, Duncan, Briber, R.M., Woodson, Sarah A.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Azoarcus - enzymology Azoarcus - genetics BASIC BIOLOGICAL SCIENCES energy HYDROXYL RADICALS Models, Molecular Mutagenesis, Site-Directed natural selection non-coding RNA Nucleic Acid Conformation Nucleotide Motifs ORIENTATION polyacrylamide gel electrophoresis RNA RNA Folding RNA, Catalytic - chemistry RNA, Catalytic - genetics RNA, Catalytic - metabolism Scattering, Small Angle STABILITY Thermodynamics X-Ray Diffraction
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