Arp2/3 complex-dependent actin networks constrain myosin II function in driving retrograde actin flow

The Arp2/3 complex nucleates actin filaments to generate networks at the leading edge of motile cells. Nonmuscle myosin II produces contractile forces involved in driving actin network translocation. We inhibited the Arp2/3 complex and/or myosin II with small molecules to investigate their respectiv...

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Veröffentlicht in:	The Journal of cell biology 2012-06, Vol.197 (7), p.939-956
Hauptverfasser:	Yang, Qing, Zhang, Xiao-Feng, Pollard, Thomas D, Forscher, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin-Related Protein 2-3 Complex - metabolism Actins - metabolism Actins - ultrastructure Animals Aplysia - metabolism Aplysia - ultrastructure Cells Growth Cones - metabolism Growth Cones - ultrastructure Kinases Microscopy, Electron Molecules Motility Myosin Type II - metabolism Proteins
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